A New Method Of Dealkylation For The Ethers And Synthesis Of The Indazoles

This thesis includes two parts, first part, a new method of dealkylation for the ethers isstudied. It was a convenient and practical method, for it has the advantages of low cost andgood selectivity. Second part, a series of indazole derivants were synthetized from thelow-cost raw materials, the synthesis process was easy and convenient. These indazolecompounds include N(1)-, C(3)-, C(4)-and C(5)-substituted indazoles, which are hot-spotstructure of biologically active compounds. And they could be further modified, which laythe foundation for follow-up research work. This thesis contains three chapters:Chapter1: PrefaceChapter2: The hydroxys were transformed into ethers after being protected by alkyl,and the ethers could process a dealkylation reaction and turn back hydroxyl compounds whentreated with boron trifluoride and sodium iodide. It is a good method with the advantages oflow cost and good selectivity.Chapter3: A series of indazole derivants were synthetized from the low-cost rawmaterials, the synthesis route was easy and convenient. These compounds include N(1)-,C(3)-, C(4)-and C(5)-substituted indazoles, which are of great interest as partial structure ofbiologically active compounds.