The Cell Model Considering The Role Of Microfilament And The Simulation Of Cellular Pseudopod

As the basic unit of life, the cells can resist the stimulation from cell physiological environment and the external factors, with certain structure and mechanical properties. According to the research, it shows that the change of cell structure and mechanical properties, not only can lead to the change of cell morphology, but also can make the cells have abnormal physiological function. Although the transmission mechanism between mechanical force and biological signal in living cells is still not clear, as primary task, the study of the responses cells under mechanical force is of great importance. Therefore, it becomes a focal point in biomechanics to find out the cell structure, establish and improve the models of cells.In this paper, with the help of Abaqus, the cell of fluid-solid coupling model is establish to simulate the passive deformation and the active deformation of cells. This work includes three parts. They are :(1) the cell passive deformation model without the microfilament is established and is co mpared with the cell experiments to validate the rationality of the fluid-structure coupling model;(2) the cell passive deformation model with the microfilament is established and is compared with the cell model without the microfilament, to study the effect of the existence, the quantity and the direction of microfilament on the deformation of the cell;(3) the cell active deformation model is established to simulate pseudopod extend, discussing the cause of pseudopodia different shapes.