Mechanisms Of REGγ’s Functionary Regulation

REGy, known as a member of 11S proteasome activator, can promote protein degradation through ubiquitin and ATP independent pathway, which is unique among its counterpart REGa and REGβ.Recently REGy has been reported to be related with several carcinoma progression. In our research, potential phosphorylated sites have been raised on its C-terminal for the first time, which can affect turnover of P21 and HCV core protein. As a homoheptamer complex, K195 acetylation is required to form this complex and contribute to its protein stability. Besides, NIP30 can interact with REGy while phosphorylated on its C-terminal, which in turn inhibit P21 degradation by REGy and lead to cell proliferation inhibition and cell cycle arrest. We have covered several pieces of novel work and revealed the regulatory mechanisms of REGy, which would certainly benefit future research in this field and draw an even vivid picture of REGy.