Research Of Impulse Radiating Focusing Antenna In Bioelectric Applications

At present, the traditional cancer treatments such as surgery, radiation therapy and chemotherapy treatment, the mechanism of which are to damage or inhibit the growth and proliferation of tumor cells, can only delay the progression without achieving the purpose of cure. The method with micro / nanosecond electric pulses requires the treatment of cancer using invasive / minimally invasive needle electrode or electrode array in a way as to lead to the tumor tissue, which may have serious negative effects on the patient's physical and mental will. To find an effective way to kill tumor cells and improve the quality of life of cancer patients with non-invasive treatment has been the expectations of both doctors and patients.By reducing the pulse width of high intensity electric field from nanosecond to sub-nanosecond or picoseconds level,it will lead the research of pulses on the structure and function of organisms to a new field. Considering the application of non-invasive treatment and window effects of cell apoptosis targeted induced by electric pulses,method of non-invasive treatment of tumors was proposed in this research. With picosecond pulse being focused on the tumor tissue by using Impulse Radiating Antenna(IRA),the mitochondrial transmembrane would change to collapse under which the tumor cells could be targeted induced to apoptosis in mitochondrial pathway.Picosecond electric pulses with the time-domain ultra-wideband antenna technology have excellent directivity and fine maneuverability. Based on the theory ultra-wide-band antenna,we designed an Impulse Radiating Antenna by which picosecond pulses can be radiated and some preliminary optimizations of the antenna were made. Whileβwas 90°~95°andθwas 30°~35°,the maximum E-field distribution could be achieved and the analytical field strength of target location can be got with the aperture-field analysis. At the same time, the gain and field pattern of the antenna are stable, and the voltage standing wave ratio is less than 2. And the pulse of focusing region maintains the input impulse characteristics, while the full width at high maximum of the E-field distribution generated in x-axis direction is less than 20mm, with y-axis and z-axis 10mm.The antenna is designed with high time resolution and spatial resolution. Considering the introduction of the theory of dielectric lens focused in the target location where to place dielectric lens, which can make the electric pulses spread in coupling medium in a non-attenuated way, with as little as possible decay, so a higher E-field intensity distribution can be achieved in target position.