Study On Structure And Design For The Platform Of Molecular Optical Simulation Environment

Molecular imaging technique has been achieved a rapid development in the past decade and obtained wide application in gene expression, tumor detection and drug development of small animal experiments and pre-clinical trials. As an emerging technology, molecular imaging has become a new research hotspot in the field of medical imaging for the new century.Among the modalities of molecular imaging technique, optical molecular imaging (OI) is one of the important branches. Compared with the other modalities, OI has the advantages of high time resolution and sensitivity, non-invasive and low-cost. It can be used to reflect the details of the process of molecular biology in vivo. As a new imaging modality, the application of molecular imaging technique not only needs the efforts on basic theories and algorithms, but also needs the visualization techniques and the development of platform.Molecular Optical Simulation Environment (MOSE) is a simulation platform developed by our research group, which realized the simulation of a whole process of photon propagation in biological tissues and in free space. Based on Monte Carlo method, MOSE can accurately describe various behaviors of photons in biological tissues (such as absorption, scattering and refraction); and in free space, MOSE used Lambertian source theory of diffuse light to guarantee the accuracy and effectiveness of the simulation results. Besides the introduction of these two methods in MOSE, the main work of this thesis is focused on the design of MOSE software architecture.This thesis mainly presented the study of software architecture of MOSE and the implementation of each module. First of all, the structure and main modules of MOSE are introduced. Then, the parameters and functions of each module are described. Secondly, the user interface which is friendly and convenient is described. Also, the relevant functions of the interface are introduced. Thirdly, simulation procedure and the relevant results are presented specific to the functions. Lastly, conclusions and prospects of MOSE are addressed.