Preparation And Preliminary Drug - Loading Properties Of Nanocomposites Used As Drug Carriers

The drug carrier not only avoids tissue resistance but also changes the releasing rates of drug to enhance drug therapy through the use of appropriate materials. Inorganic material, which is of the morphology controllability, large surface, optical properties, gives it the potential delivery development. Composite nanoparticles are required for the good biocompatibility and high drug loading, they must be able to keep continuously drug release. This article will study three different structures of inorganic nanoparticles and study its preliminary drug performance. 1、The preparation and drug loading research of new GO/porous SiO₂-NH₂Mesoporous SiO₂-NH₂ was synthesized by removing the templating agent of acid extraction and high-temperature calcination methods. GO/porous SiO₂-NH₂ was synthesized through the different morphology mesoporous materials SiO₂ by a series of surface electrostation. Mesoporous SiO₂ prepared by acid extraction method was easy to combine with GO because of uniform pore size and order pore. It had been researched to sustain drug release in simulated intestinal fluid. Drug loading increased to 25.50%, and the cumulative drug release grew up to 100% after 56 h in simulated intestinal fluid. GO/porous SiO₂-NH₂ has high drug loading and releasing properties. 2、The preparation and drug loading research of new GO/CaCO₃-NH₂GO/CaCO₃-NH₂ was prepared by reverse micro-emulsion method and the different morphologies of nano-CaCO₃ were prepared with two surfactants（CTAB and Tween-80）. Compared with rod nano-CaCO₃, the surface area of diamond-shaped CaCO₃ was larger. Drug loading of GO/CaCO₃-NH₂ increased from 19.56% to 39.70% and cumulative drug released lastly 72 h when drug reached 53.49%. The composite material in the predetermined（0-75 μg/ml） concentration had good biocompatibility. With contained CaCO₃, the composite is embedded in vivo and will play a role in the field of bone repair sustained area. GO/CaCO₃-NH₂ in the drug delivery system may be provided. 3、The preparation and drug loading research of SiO₂-NH₂/CuIn S2The red fluorescence dots（CuInS₂） were prepared with organic-phase and hydrothermal synthesis methods and its structures were researched by UV, fluorescence. The emission wavelength of CuInS₂ quantum dots were 655 nm, the shapes were smooth and symmetrical. Composite materials not only increased the biocompatibility and compatibility of oil-soluble dots but also the dispersion and stability of water-soluble dots. The fluorescence intensity of SiO₂-NH₂/oil-soluble CuInS₂ was more stable. Drug loading increased 29.47% and drug release had sustained 12 h when drug reached 64.21%, the composite material had a sustained-release effect. Fluorescent nanoparticles with drug were stable which provided the properties in biological image and targeting- drug in vivo.Conclusion: As drug carriers GO/porous SiO₂-NH₂ and GO/CaCO₃-NH₂ have high drug loading, good release property and the desired biocompatibility in a certain range of concentration of the materials. They have the good application in the drug delivery area. SiO₂-NH₂/CuInS₂ has uniform particle size and stable fluorescence, containing high drug-loading, slow-release effect. It can be used as a new type of multifunctional nanoparticles to achieve drug-located, release and biological image.