Study On Preparation And Drug Release Of Medicinal Chewing Gum

Chewing gum drug delivery system is a new type of drug delivery system with high patient compliance, quick onset of action and other significant advantages. In this study, baicalin and glycyrrhetinic acid were chosen as the model drugs, and the solid dispersion together with the tabletting gum base were used to prepare the chewing gum. The formulation design, the prepararion process and the drug release profiles were investigated to explore the characteristics of the drug-containing chewing gum.This study used medicinal drug/polymer (Cutina, Soluplus Kollidon SR) as as the dispersion carrier in preparing solid dispersion, which improved chewing gum preparation process adaptability and in vitro drug release properties, it also helped to improve the dispersion and stability of drugs. This study established the process "drug preparation-granulating-blending-tabletting" of making chewing gum. Results showed that when the dispersed carrier content lower than 30%, the chewing gum had good optical property, Kollidon SR and gum base had the best compatibility. After optimizing the proportion of baicalin/Cutina-Kollidon SR (1:3:3), the chewing gum had a good sense of compliance.Baicalin/Cutina or glycyrrhetinic/Cutina solid dispersion could decrease the release rate of drug from the chewing gum. Baicalin/Cutina-Soluplus or baicalin/Cutina-Kollidon SR solid dispersion was benefitial to futher regulates the release of baicalin. Balanced all of the factors, it was considerred that the differences in the properties of the carriers and the ratios between the polymers were the two key factors. Based on the reasonable combination of different preparation process and the carriers, a sustained, steady, and complete release of baicalin or glycyrrhetinic within 30 min could be accquired during the chewing process. The parameters obtained from fitting the experimental data to the Peppas equation showed that baicalin/Cutina or lycyrrhetinic/Cutina solid dispersion could change the way of relase kinetics from the diffusion to anomalous diffusion. Moreover, the diffusion of baicalin from baicalin/Cutina-Soluplus or baicalin/Cutina-Kollidon SR chewing gum could be enhanced.