Analysis Of The Components Of Astragalus And Hypoglycemic Capsules And Its Mechanism

Pre-diabetes (Prediabetes),also known as the Sugar Regulation damaged (I-mpaired Glucose Regulation, IGR),is the intermediate state from health to diabe-tes. Diabetes is a kind of chronic permanent illness, varied chronic complicat ions caused by thelong-term chronic hyperglycemia and metabolic disorders are irreversible. Pre-diabetes, however, is a reversible process, and early interventi on in this population, the incidence of type 2 diabetes can reduce the risk of 58%, showing that pre-diabetes research is important to prevent the onset and progression of diabetes.There are early intervention for diabetes lifestyle intervention and drug int ervention two kinds. Among them, Chinese medicine, Chinese medicine check against the application, have pre-diabetes intervention in some effect, but becau se of clinical symptoms of pre-diabetes population is not obvious, and some ev en have no symptoms, which makes it difficult for the diagnosis and treatment of traditional Chinese medicine. In addition traditional Chinese medicine ingre dients too complex, its mechanism of action is difficult to clear, hindered its p romotion in a wider range of applications. Therefore, screening and evaluation of proprietary active ingredients of traditional Chinese medicine research in the field has become an important preliminary task diabetes.Among them, in 2011 approved the listing of the days of Qi hypoglycemi c capsules, as pre-diabetes and diabetes patients on the basis of medication, ap peared in the "Chinese Type 2 Diabetes Prevention Guide" (2013, latest editio n), "TCM Diabetes Prevention Guide" (2007 The latest edition), "TCM diabetes prevention Guide" (2014, latest edition). Hypoglycemic Capsules Astragalus Qi days, TCS, Dendrobium, ginseng, Ligustrum lucidum, Digupi, berberine (Stea med), dogwood, Eclipta, gallic 10 Chinese herbal medicines. Its effectiveness a s a heat Sheng Jin, Qi Yin, kidney astringent fine. Indications heat injury yin, Qi and Yin deficiency syndrome. The present study showed:Qi days Hypoglyc emic Capsules can effectively lower blood sugar, improve insulin sensitivity an d lipid levels, and its mechanism of action generally directed to protect and re gulate islet cell function. However, the active ingredient days Qi hypoglycemic capsules composed of what is? What role are on target? Are there any other mechanism yet to be discovered? A complete explanation on how to access pa noramic day Qi hypoglycemic capsules from the molecular level?...... Become academic questions to be answered.In response to these important scientific proposition, the paper pre-diabetes guidelines recommend the drug days Qi hypoglycemic capsules of the active i ngredient and its mechanism as the main research content, evaluation of the eff ectiveness of traditional Chinese medicine in the field of research and safety, u sing liquid chromatography-mass spectrometry method for the determination d ays Qi hypoglycemic capsules of the active ingredient, and further utilization o f open source database, to identify targets of the active ingredient; Construction of Drug-target-disease network; on this basis, interaction and biometric co mponent targets between learning pathways. The main results of this thesis and academic contributions are as follows:1. LC-MS results show that day Qi hypoglycemic capsules main active in gredients include:Mulan base berberrubine Africa tetrandrine, methyl berberine, berberine, Palmatine, Rhodiola glycosides, caffeic acid, chlorogenic acid new (5 caffeoylquinic acid), chlorogenic acid (3-caffeoylquinic acid), hidden chloroge nic acid (4 caffeoylquinic acid),3-ferulylquinic acid,4 ferulylquinic acid,5-fe rulylquinic acid astragaloside, different ferulic acid, kaempferol -3-0- rhamnosid e, kaempferol -7-O- glucoside, calycosin, ginsenosides Rg1, ginsenoside Ro, fe rulic acid, ginsenoside Rg6/F4/isomer, ginsenoside Rg3, ginsenoside Rf, gin senosides Rg5/RK1/isomer, ginsenoside Ro, Swertia glycosides, Cork lacton e 29 kinds. Through literature, we added a wealth of basic information, physic al and chemical information, configuration information, as an active ingredient days Qi hypoglycemic capsules screening and evaluation of research provided t he basic data.2. Receive many targets, this paper filter all can look up the literature rep orted, according to its role in the body, the corresponding component berberine, berberis red, caffeic acid, alkali, green original acid, chlorogenic acid, chlorog enic acid, kaempferia galanga phenol -7-O- glucoside, ferulic acid, ginseng saponin Rg3 for days stilbene hypoglycemic capsule in the treatment of diabet es and pre-diabetes main active ingredients.The results of a comprehensive study of the whole, we believe that:Tianq i hypoglycemic capsule can improve insulin resistance, regulation of glycogen s ynthesis, decomposition and metabolism, modulating the glucocorticoid regulate blood pressure. Basic description of the pharmacodynamic mechanism of action days Qi hypoglycemic capsules.