| Purpose:To reveal the inflammatory reaction mechanism of replenishing qi and strengthening the spleen and nourishing blood and eliminating phlegm for CAD stable angina pectoris.Material and method:1. Subjects:The clinical trial design was carried out by using multi center, blind method, and randomized and parallel control group. The treatment of replenishing qi and strengthening the spleen and nourishing blood and eliminating phlegm, combining with conventional western medicine were used for CAD stable angina pectoris with spleen deficiency and phlegm syndrome.2. Grouping method:First recruit subjects according to the selection criteria, and then divided the 160 subjects into test and control group at a proportion of 1:1 by the SAS statistics software. Each group has 80 cases.3. Interventions:Subjects in test groups were given TCM granule which replenishing qi and strengthening the spleen and nourishing blood and eliminating phlegm (including Codonopsis pilosula, Astragalus mongholicus, Atractyiodes macrocephala, Rhizoma Pinelliae, etc), combining conventional western medicine; control groups were given placebo TCM granules (10% of the constituents of the test groups), combining conventional western medicine. The course of treatment is 12 weeks.4. Observation method:general situation, angina score, Seattle angina questionnaire, inflammatory indexes. In addition to the general information, week0, week 4 and week 12 are taken as the information collection points.5. Statistical methods:data based resume, application of SPSS for windows 17.0 collation and analysis of data. The measurement data were (x±s), and p<0.05 was statistically significant.Results:The PPS data set was selected, and the finally finished cases are 77 in the test group and 73 in the control group.1. Angina score:The test group was statistically significant, comparing week 4 and week 12 with week 0, and the control group was statistically significant, comparing week 12 with week 0. The difference was statistically significant, comparing week 12 of the two groups. The test group was better than the control group.2. Seattle angina questionnaire:The 5 dimensions of the test group was statistically significant, comparing week 4 and week 12 with week 0, the control group was statistically significant, comparing week 4 and week 12 with week 0. AS dimension was statistically significant, comparing week 4 and week 0 of the two groups. The test group was better than the control group.3. High-sensitivity C-reactive protein (hs-CRP):1) The test group was not statistically significant, comparing week 4 with week 0, (P>0.05). It was statistically significant, comparing week12 with week 0, (P<0.05).2) The control group was not statistically significant, comparing week 4 and week 12 with week 0, (P>0.05).3) It was not statistically significant, comparing week 4 of the two groups, (P>0.05). It was statistically significant, comparing the week 12 and Δ (week 12-week 0), (P<0.05). The test group was better than the control group. Details are on the table 6-8.4. Monocyte chemotactic protein-1 (MCP-1):1) The test group was not statistically significant, comparing week 4 with week 0, (P>0.05). It was statistically significant, comparing week 12 with week 0, (P<0.05).2) The control group was not statistically significant, comparing week 4 and week 12with week 0,(P>0.05).3) It was not statistically significant, comparing week 4 of the two groups, (P>0.05). It was statistically significant, comparing the week 12 and Δ (week 12-week 0), (P<0.05). The test group was better than the control group.5. Vascular cell adhesion molecules-1 (VCAM-1):1) The test group was statistically significant, comparing week 4 with week 12, (P<0.05).2) The control group was statistically significant, comparing week 4 with week 0, (P<0.05). It was not statistically significant, comparing week 12 with week 0, (P>0.05).3) It was not statistically significant, comparing week 4 of the two groups, (P>0.05). It was statistically significant, comparing the week 12 and Δ (week 12-week 0), (P<0.05). The test group was better than the control group.6. Scavenger receptor A (SR-A):1) The test group was not statistically significant, comparing week 4 and week 12 with week 0,(P>0.05).2) The control group was not statistically significant, comparing week 4 and week 12 with week 0, (P>0.05).3) At each point of time, there was no significant difference between the two groups (P>0,05). The test group had declined, as same as the control group. The test group had no obvious advantage.7. Scavenger receptor B (SR-B):1) The test group was not statistically significant, comparing week 4 and week 12 with week 0, (P>0.05).2) The control group was not statistically significant, comparing week 4 and week 12 with week 0, (P>0.05).3) It was not statistically significant, comparing week 4 and week 12 of the two groups, (P>0.05). It was statistically significant in Δ (week 12-week 0), (P<0.05). The test group was on the rise, but the control group had declined. The test group was better than the control group.Conclusion:The reaction of High-sensitivity C-reactive protein (hs-CRP), Monocyte chemotactic protein-1 (MCP-1), Vascular cell adhesion molecules-1 (VCAM-1), Scavenger receptor A (SR-A) and Scavenger receptor B (SR-B), revealed the inflammatory reaction mechanism of replenishing qi and strengthening the spleen and nourishing blood and eliminating phlegm for CAD stable angina pectoris. |
PDF Full Text Request