Effects Of "Living-High And Training-Low" On The Vascular Endothelial Cell Growth Factor(VEGF),Basic Fibroblast Growth Factor(bFGF),NO And NOS In The Lung Of Mouse

It is recently supposed that the HiLo (Living-high Training-low) model, an approach to altitudetraining by living high while simultaneously training at low elevation, in order to improve one's endurance performance. This training method overcomes the shortcomings when training in altitude environment, particularly the negative effects to the blood and oxygen supply to muscles and combination of proteins. Meanwhile, living in hypoxia environment can improve the ability of making use of oxygen and the ability of metabolism. Therefore, HiLo is an effective training method. HiLo not only maintains the advantages of excavating the potential in altitude training but also avoids the disadvantages of difficulty in increasing the training burthen on altitude. So it is regarded as a breakthrough in the history of altitude training.Within the last decade, many factors have been found to be able to influence the formation of new capillaries, among which VEGF seems to be the most important mediator of hypoxia-induced angiogenesis. b-FGF is a potent mitogen for endothelial cells, smooth muscle cells, and fibroblasts .Furthermore, b-FGF can upregulate VEGF and NO production. VEGF exists in a variety of cells but is mainly distributed among skeletal muscular capillary. It suggests that VEGF and its gene expressions play an important role in the growth of new capillary under hypoxia conditions.With the deepening of the study in the relationship between NO and movement, it has been found that NO plays a critical role in movement. Therefore, it is possible that NO has some relation with the mechanism of "Living-high Training-low".Researches testify that VEGF can stimulate the endothelial cell of human navel vein to release NO. VEGF stimulate vascular endothelial cell to release NO acutely, which might have some relations that VEGF induce to increase Ca²⁺ level in cell and...