Effects Of Different Weight Training On Bone Biomechanical Properties And Expression Of IGF-I In Aged Rats

With the social progress, economic development, rapid upgrading of science and technology, the social problems of population aging is increasingly becoming the focus, and how to extend the life and quality of life of the elderly is top priority. Therefore, how to delay aging has also become a hot spot. The results show that morphology and function of motor system degenerative changes having taken place, is one important manifestation in aging process. In recent years, bone loss prevention in elderly people has got more and more attention. Exercise can improve bone metabolism and prevent osteoporosis and bone loss, which is an important means of increasing bone density. In different age, taken different intensity and form of exercise, also have different the effect on the form and function of bone. This article shows that natural aging rats whose bone mass is sharply declining were adopted different weight training, to observe that the weight training effect on bone biomechanical properties and IGF -1 expression of aged rats in order to provide a scientific basis to prevent and treat osteoporosis.Thirty-two 17-month male natural aging Wistar rats were randomly assigned into 4group: little intensity group (L), moderate intensity group (M), high intensity group (H), and control group (C). After 8 weeks, all groups rats were killed to measure bone, serum alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRACP) level, the biomechanical properties of bone And IGF-I expression in bone.Results:(1).Compared with group C, the biomechanical properties of bone were higher significantly (P<0.05), ALP level was very higher significantly (P<0.01), IGF-I express level was higher significantly (P<0.05), but TRACP level was lower significantly (P<0.05) in group M.(2). Compared with group M, TRACP level was higher significantly (P<0.05), ALP level was lower significantly (P<0.05), the biomechanical properties of bone were lower (P<0.05), but IGF-I express level was not clear (P>0.05). Conclusion:Result showed that proper weight training can increase older male rats serum ALP, promote bone formation, enhance IGF-I expression in bone, optimized the mechanical properties of bone biology, delay bone loss because of the aging, and slow down bone tissue metabolism and expression of IGF-I levels decreased. It should be noted that moderate intensity weight training is more useful to improve the bone mechanical properties and the expression of IGF-I in aged rats.