| ObjectiveAges were often burn wounds, usually in hot blood. the skin, once damaged, will be made to protect the environment stable features have been destroyed or lose, and may lead to a pathological physical and immunization, metabolic, a series of complex change, each component body is dirty and system of functional, metabolic, and form the changes. therefore, the burns he received treatment process is directed at the body treatment and want to magnify the part that is wound for medical treatment. granulocyte -macrophage colony stimulating factor (rhGM-CSF) because it has stimulated the marrow stem cells differentiated and enhance the proliferation of the cell functions, promoting and resistance to infection and inflammatory reaction of activity and wide application in clinical research. GM-CSF a factor of gelatin applied to the patient was a cut wound and external use only rhGM - CSF gel to burn (hot) the effects and impact of factors, as in the clinical get good results in medical to provide.Observation Object and Methods1. Case selectionChoose burns shallow ii, ii of the deep as to the 16, 18 ~ 65 ages, were divided into two groups. The two groups of cases of age, sex, course of disease and encourages type basically unanimous, and after injury and encourages to hospital in 48h and within the area of the body surface area of 30%. It was eliminated that critical patients, with severe complication reported and with a body of the main organs, the serious illnesses in the drug is allergic tendencies, encourages the large area in the body surface area of 30% ;women of age of sucking and in pregnancy.2.Methods of drugs usedThe observation group ( rhGM-CSF gelation group) shallowⅡo burn wound with direct used rhGM-CSF gelation, cover sheets at 1mm andⅡo of the wound after a scab rhgm also use gel - csf that encourages and encourages the situation on the dressing wounds; The control group with the rhEGF was peptide seasoning group of the wound in the shallowⅡo directly with a gold for peptide sprays fiberswill work, and even encourages doses to encourages against erosion andⅡo to the wound with a scab when they are evenly fiberswill work, and encourages doses encourages not to get down to the erosion, and encourages the situation on the dressing up. The time observation was 28 days.3. Observation indicatorsObservation indicators include wound to heal wounds, at any time, from time to time to heal the wound healed capacity rates, encourages, and during observation use of drugs have side effects.4. Statistics methodAt the end of clinic observation , The data was collected and Statistical processed. Statistical software 13.0 was used. F test was choose many groups comparison and t test was choose between two groups.Results1. Encourages appearanceEncourages application rhGM - CSF gel first, and necrosis of tissue secretion is more, 3 ~ 5d and necrosis of tissue, such as secretions came clean and clear, fresh and encourages inflammation subsides are obvious reaction week. any patient is always feeling after a week, the wound was not pregnant and most of the bacteria to develop The shallowⅡo of the burns he received a wound to heal 7 ~ 10d ;The deepⅡo of the wound after two weeks in the skin and visible skin island growth has been speeded up remarkably and the healing time was 21~ 25d.2. Wound to heal timeThe healing time treatment shallowⅡo wound of rhEGF of was 12.25±2.06d, and deepⅡo wound was 24.75±2.50d; The healing time treatment shallowⅡo wound of rhGM-CSF geliation of was 7.00±1.63d, and deepⅡo wound was 15.75±1.26d; rhGM-CSF gel treatment shallowⅡo degrees and deepⅡo of the wound healed time is less marked than in the gold was peptide seasoning in the short(P<0.05).3. Influence of wound to heal rateTreatment process, both have any drug with the time to heal burn wounds ii degrees on the rate of increase significantly ( P < 0.05 ). Get in the same time, rhGM-CSF gel group ii on the wound is cicatrized rate is significantly higher than the king was peptide spray group (P < 0.05 ). To any 10d, rhgm - csf gel group ii of the burns he received treatment by his wounds to heal. the whole. To get the 4d, rhGM-CSF gel group ii of the deep wound to heal rate is significantly higher than the king was peptide spray group (P < 0.05 ). And then to get the 10d, rhGM-CSF gel group and gold for peptide spray set of treatment of the burn patients ii wounds heal rate is the obvious differences (P> 0.05 ).4. Influence of capacity rate of heal woundOn the treatment process, two types of drugs have any time as the wound healed volume ii of the burns rate noticeably (P<0.05 ), and in the same time, any rhGM-CSF gel groupⅡo on the wound is cicatrized capacity rates are lower for spray set rhEGF (P<0.05). To any 10d, look at cases in rhGM-CSF gel group of paleⅡo of the burns he received a wound to heal all wounds healed, the volume ratio is 0. When drugs are eight days in rhEGF group, deepⅡo wound to heal burn patients ii of the volume ratio began to drop off significantly (P <0.05); When drugs was used six days in rhGM-CSF gel group, the capacity to heal the wound began to drop off significantly (P <0.05); Drug used 8d to 10d, rhGM-CSF gel group of wounds to heal on the volume ratio is noticeably lower than gold was peptide spray group (P <0.05), and the 4d and 6d, the two groups of deep wound to heal burn patientsⅡo of the volume ratio is significantly (P>0.05 ).5. Toxicandside-effectThe two groups of cases have found no apparent in the treatment of sick and the symptoms, treatment and liver and kidney function and electrolytes and blood, and routine urine no exceptions, have not seen the partial or an organization such growths.ConclusionsrhGM-CSF gel can be rapidly improved ii of the burns encourages inflammation of the reaction. The wound healedⅡo of the burns he received a short time because of the gold peptide spray. The wound healed ii of the burns he received marked by rapid rate rhEGF peptide spray. the wound to heal burnⅡo of the volume ratio is for small rhEGF peptide spray. rhGM-CSF gelⅡo to the wound is healing burns in ten days than on the burns he received a wound. rhGM-CSFⅡo gel and gold for peptide spray are no significant side effects.
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