Research Of Active Protein C In Patients With Pulmonary Thromboembolism

Objective: The analysis of activity protein C to patients with pulmonary thromboebolism (to call for short name pulmonary thromboebolism PTE) diagnosed in the hospital. The aim is to explore the change of APC with the age, and the difference between different nations, genders. Methods: Clinical data of 110 patients with PTE between January of 2006 and December of 2009 is analyzed retrospectively. The aim is to explore the relativity between APC and age, and the change of APC with the rising of age. The different level of protein C and the reduction of protein C between two groups are beyond 60 years and below 60 years. The second aim is to find the difference between the level of protein C and the reduction of protein C in different genders, nations. Results: 1. There are 72 men and 38 women among 110 cases, and their ages appear positive skewness distribution. The median is 61 years. The smallest age is 21 years old, and the oldest age is 82 years in the data. The median of age about men is 65 years, and the smallest and the oldest age is 21 years and 82 years respectively. The median of age about women is 62 years, and the smallest and the oldest age is 28 years and 72 years respectively. There is no difference between the ages of two groups. The absent incidence rate of active protein C in 60 years eld is obviously higher than the younger. 2. The incidence rate to absence of protein C in PTE patients is 26.4%. The average level of active protein C appears decreasing along with the patients'age increase, and the result shows to be no difference. The coefficient correlation is -0.041, P=0.668 which shows there is no linear correlation. 3. The median of active protein C among men and women is 83.0% and 86.0% respectively. The compared result of two groups is P>0.05 showing that there is no difference. The absent incidence rate of active protein C is the below. There are 55 men with normal level of protein C, and 17 men with low level of protein C. 26 women with normal level of protein C and 12 women with low level of protein C. The result is P>0.05, and there is on statistical significance between two groups. 4. There are 69 cases of Han nationality and 41 cases of Uygur nationality. The result compared to the ages of two groups is not significant (P>0.05). The median of active protein C is 84.0% and 83.4% respectively among the Han nationality and the Uygur nationality. Absence of active protein C is 48 cases of Han nationality with normal level of protein C, 21 cases with low level; 33 cases of Uygur nationality with normal level of protein C, and 8 cases with low level of protein C respectively. There is no evident statistical significance (P>0.05). Conclusion: 1. The average level of protein C is decreasing with the age becoming older. But there is no linear correlation. 2. The absent incidence rate of active protein C in 60 years eld is obviously higher than the younger. 3.There is no evident difference in the level of APC and absent incidence rate of active protein C between different genders. 4. The average level of protein C and absent incidence rate of active protein C has on difference in Han nationality and the Uygur nationality.