Association Between Polymorphisms Of Il-1b-31,il-10-819 And TNF-A-1031 Genes And Susceptibility Ofgastroduodenal Diseases

Objective: Analysis of population IL-1B-31, IL-10-819 and TNF-A-1031 polymorphism and susceptibility to gastroduodenal diseases the relationship between the clinical diagnosis , prevention of these diseases for more than provide new ideas and methods.Methods : Using PCR-restriction fragment length polymorphism method and allele-specific PCR detected 48 cases of chronic gastritis, 51 gastric ulcer patients, 46 duodenal ulcer patients, 43 cases of gastric cancer patients and 100 healthy controls population IL-1B-31, IL-10-819 and TNF-A-1031 of the gene polymorphism.Results: In this study population IL-1B-31, IL-10-819 and TNF-A-1031 site showed the C / T polymorphism, a C / C, T / T, C / T genotype of three . IL-1B-31 and IL-10-819 genotypes in the disease group and control group in the distribution of statistically significant no. In the gastritis group, TNF-A-1031 genotypes in (T / T, 50%; T / C, 40%; C / C, 10%) and the control group (T / T, 73%; T / C , 25%; C / C, 2%) compared with distribution of difference was significant (χ2 = 9.975, P <0.05). In the gastric ulcer group, TNF-A-1031 genotypes in (T / T, 49%; T / C, 43%; C / C, 8%) and the control group (T / T, 73%; T / C, 25%; C / C, 2%) compared with distribution of difference was significant (χ2 = 9.464, P <0.001). In the duodenal ulcer group, TNF-A-1031 genotypes in (T / T, 72%; T / C, 26%; C / C, 2%) and the control group (T / T, 73% ; T / C, 25%; C / C, 2%) compared with distribution of difference was significant (χ2 = 9.840, P <0.05). In gastric cancer group, TNF-A-1031 genotypes in (T / T, 50%; T / C, 41%; C / C, 9%) and the control group (T / T, 73%; T / C , 25%; C / C, 2%) compared with distribution of difference was significant (χ2 = 9.335, P <0.001); Logistic regression analysis: carry TNF-A-1031T / T carriers, carrying TNF- A-1031 C / C are the risk of occurrence of gastritis was OR = 7.60 (95% CI: 1.38-41.77); and carrying TNF-A-1031T / T carriers, carrying TNF-A-1031 C / C have occurred where the stomach the risk of ulcers was OR = 5.84 (95% CI: 1.00-33.84); and carrying TNF-A-1031T / T carriers, carrying TNF-A-1031 C / C have occurred where the risk of duodenal ulcer was OR = 7.94 (95% CI: 1.44-43.67); and carrying TNF-A-1031T / T carriers, carrying TNF-A-1031C / C the risk of gastric cancer was OR = 6.95 (95% CI: 1.19- 40.63)Conclusions: IL-1B-31 and IL-10-819 genotypes in Helicobacter pylori associated gastrointestinal diseases are not related. TNF-α-1031 polymorphism and gastritis, gastric ulcer, duodenum, gastric cancer susceptibility.