The Efficacy And Safety Of Fondaparinux For The Treatment Of Acute Coronary Syndrome(acs): A Meta-analysis

Objective: To evaluate the efficacy and safety of fondaparinux for the treatment of acute coronary syndrome(ACS).Methods: We searched Cochrane, Pubmed,Medline and China National Knowledge Infrastructure(CNKI) database for the literatures on the clinical trials of fondaparinux that published from Jan. 1980 to Feb. 2010. A manual search also performed. All data from the included studies were dealt with the RevMan 5.0 software.Results: 4 trials were finally included. For the efficacy: OR=0.90, 95% confidence interval(0.83,0.98), and Z test for the overall effect was 2.34, P=0.02. As for the safety: OR=0.64, 95% confidence interval(0.45, 0.92), and Z test for the overall effect was 2.42, P=0.02.Conclusion:fondaparinux is effective and safe for the ACS treatment and superior to unfractionated heparin and enoxaparin.