Surgery Treatment And Analysis Of Prognosis In 61 Patients With Hilar Cholangiocarcinoma

Objective:To explore the impact of clinical features and surgical procedure on survival of hepatic hilar cholangiocarcinoma(HCC)and the prognostic factors in patients with Klatskin tumor after curative resection.Methods:From 2004 to 2009,61 Klatskin tumor patients undergoing operations were included in this study.The clinical features,diagnosis,surgical procedure and follow up data were retrospectively analyzed.Factors influencing postoperative survival were analyzed using COX multiple stepwise regression mode1.Results:Of the 61 patients,30 underwent radical resection and 10 underwent radical resection plus liver leaf resection,8 underwent palliative resection,13 underwent drainage or laparotomy.The overall 1-,2-,and 3-year survival rates were 73.8%,62.3%,and 36.1%,respectively.COX analysis showed surgical approach and degree of tumor differentiation were independent prognostic factors after radical resection(P<0.05).Conclusion: (1)The radical resection is the key factor for increasing the long-term survival rate and improving the life qualities of Klatskin tumor patients(.2)Partial hepatectomy in combination with skeletonization may be helpful for increasing radical resection rate and long term efficacy.(3)Bile duct obstruction for a long time,poor liver function and remnant liver function are causes for serious complications.(4)Three-dimensional conformal radiation therapy after surgery can increase the survival rate type,but long-term results have yet to be further summed.