Study On The Effective Ingredients Of Fufang Naodesheng Prescription In The Body Absorption

The prescription of Naodesheng pian(wan)which is composed of Radix et Rhizoma Notoginseng, Rhizoma Chuanxiong, Flos Carthami, Radix Puerariae lobatae and Fructus Crataegi comes from Chinese Pharmacopoeia 2010 edition. The major actions of this recipe include promoting blood circulation to remove blood stasis and dispersing stagnation to remove obstruction in meridians and collaterals.It is indicated for sequelae of apoplexy and dizziness due to stagnant blood in meridians and collaterals.It is applicable to cerebral arteriosclerosis,stoke and sequelae of cerebral hemorrhage.It has good effects testified by the clinical applications.The preliminary studies have identified effective substance fractions of the Naodesheng preparation. The thesis studies on the effective substances of the preparation simulate absorption in the body through the liposome modeling of biomembrane technology, and studies on serum pharmacochemistry. In order to know the effective substances of Fufang Naodesheng in the body absorption.The effective components of Fufang Naodesheng Prescription, interacted with liposome, were analyzed and identified by the balanced dialysis and HPLC coupling technique.Contrast the two sample collections which one is the effective components of Fufang Naodesheng Prescription interacted with liposome, the other is not interacted with liposome. Two groups of effective substance fingerprints for comparative analysis.Research results show that the former fingerprint peak significantly reduce because it is absorped by liposome.It test and verify the effective components of Fufang Naodesheng. The effective components of Chinese medicine after oral can play therapeutic effects must through the blood circulation. Based on the previous studies,in order to further explore the efficacy of Fufang Naodesheng Prescription, The thesis studies on serum pharmacochemistry. Combined effective substance fractions of Fufang Naodesheng preparation with drug model rats,through the fingerprint analysis and appraisal components of serum rats.Research results show that the Chromatogram showed 28 chromatographic peaks.Two of chromatographic peaks is an effective ingredient Puerarin, hydroxysafflor yellow A of Fufang Naodesheng preparation.That explain effective substance fractions of Fufang Naodesheng preparation display drug efficacy come into the body.Research results for the effective substances of Fufang Naodesheng in the body absorption of the thesis,further interprets the material basis of Fufang Naodesheng preparation. Aims to provide bases of the secondary development for the Naodesheng preparation.