| Objective:Yi gan Jing's anti-HBV study the clinical efficacy and safety study. It is for after nucleoside (acid) for Treatment of certain standards withdrawal relapse in patients with chronic hepatitis B At present, for the treatment of hepatitis B infection is still a problem, although the nucleoside class of drugs widely used for the general benefit of chronic hepatitis B patients, however, there is also a long course of treatment, such as lack of relapse after stopping easy. Therefore, the study of medicine from a safe and effective treatment of selected herbs, has important theoretical significance and clinical value. Hepatitis B is a net side mentor, Professor Shen Zhongyuan experience, according to the clinical practice of 28 patients confirmed that the party has a good clinical effect.Method:A total of 50 cases observed liver disease in Hubei Province Chinese Medicine Hospital outpatient, case collection time:Dec. 2007 Dec.2009, diagnosed as chronic hepatitis B, are after nucleoside (acid) for Treatment of certain standards withdrawal relapse, which LAM 29 cases, ADV 8 cases, ETV 3 cases, LDT 10cases, traditional Chinese medicine syndromes in a multi-Spleen Liver Depression. HBV DNA of all patients were> 1×10 ^ 3copies/mL, Liver dysfunction. All patients were randomly divided into treatment group (net square hepatitis B group) and control group (Hu Ju hepatitis B capsule). One treatment group,28 patients received hepatitis B net side, day 1,300ML, two temperature morning and evening services; the control group,22 patients received capsules of Huju hepatitis B (according to Pharmaceutical Co., Ltd. Jiangsu day production), each 5,3 times a day. For 6 months. Patients were observed before and after major comprehensive therapeutic effect of drugs, virological indicators of liver function and changes in the symptom score, liver spleen ultrasonography examination, and observation of safety (including renal function, three conventional and ECG).Results:1. Two groups of patients overall efficacy comparison of clinicalThe treatment group, the total efficiency (89.28%) and the control group (54.55%) compared, P<0.05, statistically significant.2. The two groups before and after treatment comparison of traditional Chinese medicine syndromes pointsComparison of the efficacy of traditional Chinese medicine symptom groups were significantly different, the clinical treatment group by 8.23±3.55 points down to 5.49±2.47, treatment group compared with those before treatment (P<0.05), there are very significant differences compared with control group (P<0.05), a relatively significant.) 3. Before and after treatment on liver functionThe two groups before and after treatment, P<0.05, significant difference; treatment group, ALT, AST after treatment compared with those before treatment between the two groups, P<0.01, there is a very significant difference; treatment group compared with the control group after treatment, P< 0.05, there are significant differences4. After treatment, the changes in HBV DNAThe treatment group,47.4% complete response rate of 13.6% compared with the control group, P<0.01, there is a very significant difference; non-response rate in the treatment group (7.14%) was significantly lower than the control group (31.8%), the two groups compared P<0.01, there is a very significant difference; treatment group was 3.57% rebound rate of 13.6% compared with the control group, P<0.01, significant difference.5. After treatment, changes in liver fibrosisTreatment group before and after treatment, HA, LA, P HI P and CIV decreased significantly, there were significant differences (P <0.05), treatment group and control group after treatment were significantly different (P<0.05).6. Safety ComparisonIn clinical studies, there was no observed net side of hepatitis B and observation of drug-related adverse reactions. Inspections were conducted before and after treatment renal function, electrocardiogram and blood, urine, feces three practices, found no abnormal changes in drug-related.Conclusion:1. Yi gan Jing of the initial treatment of hepatitis B, chronic hepatitis B patients and through the nucleoside (acid) class medications have reached a certain standard of relapse after discontinuation of chronic hepatitis B patients, the overall efficiency 88.75%, can effectively inhibit the hepatitis B virus replication, and can improve liver function, so that ALT, AST, and other serum markers of normalization.2.Yi gan Jing for the after-nucleoside (acid) class of drugs in patients with relapse after treatment discontinuation, virologic response can still produce and improve their quality of life.3. Yi gan Jing is safe, good effect is significant, worthy of clinical application...
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