| Objective:(1) a preliminary experimental study to explore parameter surgery myogenic decoction on healing of rectal anastomosis. Cytology and testing of learning from the organizational point of view to explore the low anterior resection anastomotic healing disorder surgery within the mechanism and the parameters of the therapeutic effect of myogenic Tang mechanism for the clinical anterior resection for low rectal anastomotic healing, provide A new thinking and methods; (2) Clinical study of surgery by observing the parameters of clinical OK myogenic decoction on low anterior resection of rectal anastomotic healing, to explore the parameters in the prevention of surgery myogenic Tang anterior resection of low rectal cancer postoperative anastomotic leakage of the therapeutic effect.Methods:(1) experimental study of 30 male rabbits bruising blue line low anterior resection, postoperative randomly divided into blank control group, experimental group, experimental group were given ginseng soup lavage myogenic surgery, treatment, six days after the anastomosis were cut contains The intestines of about 2cm, immunohistochemistry to detect anastomotic margin of rectal mucosa and submucosa of the b-FGF, VEGF, CD68; the same time, immediately after, respectively, after 2,6 days of taking the rabbit ear marginal vein, line CRP, WBC, NC inspection. (2) Clinical study of 92 cases of clinical selection criteria in line with selected patients were randomly divided into blank control group, experimental group, through the surgery in the rectal cavity of the anal canal retention, testing anorectal pressure,2 times/d, for 6 days. After the experimental group manometry, according to the experimental group the measured parameters of pressure, surgery myogenic Tang lavage,2 times/d, for 6 days; the same time, immediately after, respectively, after 2,6 days, in patients with venous blood collected, line CRP, WBC, NC inspection.Results:(1) experimental study of the control group and experimental group b-FGF-positive cells were 19.73±2.22 and 27.80±4.10; CD68-positive cells were 19.87±2.20 and 13.73±2.71; VEGF-positive cells were 18.20±2.81 and 24.27±2.25; were significant differences (P <0.01). The control group after the first two days CRP, WBC, NC are the highest values were (1.12±0.72,14.26±1.81,13.23±3.38), but the decline was not obvious then, still higher (P <0.05). The experimental group after the first two days CRP, WBC, NC are the highest values were (1.52±1.04,13.94±2.91,10.05±3.29), then gradually decreased (P<0.01). (2) Clinical study of anorectal pressure:control group after 1-4 days of postoperative anorectal pressure gradually increased, the first four days to reach the highest value 24.00±2.55cmH2O, then declined obvious (P> 0.05). The experimental group after the first 1-4 days of anorectal pressure gradually increased, the first four days to reach the highest value 17.84±4.31cmH2O, then gradually decreased (P<0.01).The blank group and experimental group 2days before surgery in patients with anorectal pressure was not significantly different (P>0.05),after 3-6 days of anorectal pressure control group was significantly higher than the experimental group (P<0.01).Laboratory examination:blank control group, experimental group, two groups of patients immediately after operation of the indicators no significant difference (P> 0.05). Control group after the first 2 days in patients with CRP, WBC, NC are the highest values were (155.50±16.17,14.39±5.23,15.3±2.23), but the decline was not obvious then, still higher (P<0.05). The experimental group after the first 2 days in patients with CRP, WBC, NC are the highest values were (65.97±46.74,13.22±3.61,11.42±3.74), then gradually decreased (P<0.05).Conclusions:(1) experimental study of ginseng soup can significantly promote myogenic surgery bruising blue rabbit rectal anastomotic edge of the b-FGF, VEGF proliferation, significantly reduced rectal anastomotic edge of CD68, reduces anastomotic postoperative inflammatory response, promoting bruising blue rabbit rectal anastomotic healing. (2) Clinical study of anorectal pressure increase is caused by rectal anastomotic leakage one of the reasons, the Senate, myogenic Tang lavage technique can reduce the pressure within the anus and rectum to reduce anastomotic inflammation and promote healing of rectal anastomosis. |
