Observation Of Amiodarone Prophylaxis For Ventricular Arrhythmia After Coronary Artery Bypass Surgery

Objective: Ventricular arrhythmia is a one of the more serious complications after coronary artery bypass graft (CABG). When occurred in off-pump coronary artery bypass graft (OPCABG), it will reduce ejection fraction and cardiac function, which could further reduce the quality of life, affect prognosis, increase hospital costs and even leads to death in severe cases. The experiment was designed to observe ICU the custody time and hospital stay of CABG patients'through giving them a dose of amiodarone during peri-operative and explore the preventative effect of amiodarone on ventricular arrhythmias after CABG.Methods: 125 cases of coronary artery bypass surgery patients were randomly divided into two groups, A group for the experimental group, 68 patients given preoperative oral amiodarone 200mg, 2 times / day, 7 days later changed to 200mg, 1 times / day, until the surgery, postoperative day, intravenous amiodarone, can eat later changed to oral administration of 200mg, 1 times / day, until discharged from hospital. B group, 57 cases of the control group given conventional treatment, do not give amiodarone treatment, after 3 consecutive days in ECG were observed in patients with early postoperative room, rooms as early as bigeminy, ventricular premature triple law, ventricular tachycardia , ventricular fibrillation and other ventricular arrhythmias and the occurrence of the change process. Through the two groups of patients with postoperative ECG blood-pressure monitoring results of the analysis of amiodarone on patients after coronary artery bypass surgery the heart rate, blood pressure effects. Echocardiography 5 days after review by preoperative left ventricular ejection fraction compared with the changes in order to evaluate changes in cardiac function in patients after the situation. The same time, two groups of patients with ICU care time and hospital stay were compared.Results:1 Treatment group, 68 patients, 11 cases had ventricular arrhythmia, the total incidence rate of 16.17%, of which 5 cases of ventricular premature beats, ventricular bigeminy as early as 2 cases of ventricular premature trigeminy in 1 case, ventricular tachycardia in 2 cases, ventricular fibrillation in 1 case. 57 patients in the control group, 26 cases occurred in patients with ventricular arrhythmias, the total incidence of 45.61%, of which 14 cases of ventricular premature beats, ventricular bigeminy as early as 4 cases, ventricular premature trigeminy three cases, ventricular tachycardia in 3 cases, ventricular fibrillation in 2 cases.χ2 by SPSS software to calculate both groups the overall incidence of ventricular arrhythmia comparedχ2 = 12.289, P=0.015 <0.05, significant statistical difference.2 The treatment group and the control group no significant change in blood pressure before and after treatment, P<0.05, difference was not statistically significant. The two groups after treatment in patients with heart rate slower than that before treatment, P <0.05, the difference was statistically significant.3 The treatment group before and after treatment in patients with left ventricular ejection fraction (52.5±8.2 VS 69.5±10.5), the control group before and after treatment in patients with left ventricular ejection fraction (53.8±8.5 VS 60.5±9.8), Two groups of patients with left ventricular ejection fraction after treatment than before treatment were significantly increased, P<0.05, the difference was statistically significant. One treatment group, postoperative left ventricular ejection fraction compared with the control group (69.5±10.5 VS 60.5±9.8) also improved, P<0.05, the difference was statistically significant.4 The treatment group and control group patients with shorter ICU care (1.8±0.6 days VS 2.9±1.5 days; P<0.05), hospitalization time (11.5±2.5 days VS 17.6±3.2 days; P <0.05).Conclusions: it was demonstrated in the experiment that: the using of amiodarone during CABG patients'perioperative could markedly improved cardiac function, reduce hospitalization time and costs. But have no effect on the patient's blood pressure and heart rate. The using of amiodarone during CABG patients'peri-operative could effectively reduce the incidence of ventricular arrhythmias, thereby reducing the mortality rate of patients.