| Objective:To observe the change of serum testosterone (T) level, red blood cell (RBC) levels, hemoglobin levels (Hb) in male lung cancer patients before and after chemotherapy; To explore Affect of chemotherapy on serum testosterone levels and anemia, and the relationship between serum testosterone and anemia indicators. Method:RIA was used to detect the level of serum testosterone (T) twice in these 54 patients before and after chem.; Automatic blood cell analyzer was used to detect hemoglobin (Hb) level, red blood cell (RBC) levels before and after chemotherapy. Result:(1)before chemotherapy the average level of T of lung cancer patients was (2.98±0.90) ng/ml, slightly lower than the normal reference value; After chemotherapy, the average level of T was (2.55±0.78) ng /ml, compared with that before chemotherapy; T levels decreased significantly, the difference was statistically significant(P<0.05). The average level of RBC of before chemotherapy was (3.82±0.65)×1012/L; After chemotherapy, the average level of RBC was (3.31±0.63)×1012/L, compared with that before chemotherapy, it decreased significantly, the difference was statistically significant (P<0.05).The average level of Hb of before chemotherapy was(116.37±24.04)g/L;After chemotherapy, the average level of Hb was(107.83±25.80)g/L, compared with that before chemotherapy, it decreased significantly, the difference was statistically significant(P<0.05).(2)before chemotherapy 30 (55.56%)cases of 54 male lung cancer patients were anemia patients, after chemotherapy 41(75.92%) occur anemia; Anemia after chemotherapy in the total number of patients was higher than that before chemotherapy(P<0.05), the difference was statistically significance. (3)Before chemotherapy, the T average level of group of lung cancer with anemia was(2.43±0.84)ng/ml, significantly lower than that(3.67±0.33)ng/ml in group of lung cancer without anemia, the difference was statistically significance(P<0.05). After chemotherapy, the T average level of group of lung cancer with anemia is(2.05±0.67)ng/ml, significantly lower than that(3.17±0.32)ng/ml in group of lung cancer without anemia, the difference was statistically significance (P<0.05).(4)Before and after chemotherapy, the level of serum testosterone and hemoglobin and RBC was significantly positively related(P<0.05).Conclusion:Level of serum testosterone, hemoglobin, red blood cells of male lung cancer patients after chemotherapy significantly was lower than that before chemotherapy; After chemotherapy, the incidence of anemia in male patients with lung cancer was increased; Male lung cancer with anemia was associated with decreased serum testosterone. |
