Clinical Significance Of Detection Of Serum Concentration Of UPA And UPAR In The Epithelial Ovarian Cancer

Objective To explore the clinical significance and the serum concentration of urokinase-type plasminegen activator(uPA) and it's receptor (uPAR) in the epithelial ovarian cancer.Methods The method of ELISA was used to detect the serum concentration of uPA and uPAR level in 44 patients with epithelial ovarian cancer and compared with 35 patients with benign ovarian epithelial tumors and 30 normal subjects.Results (1)The levels of serum uPA,uPAR and CA125 in the ovarian cancer were significantly higher than that in the benign ovarian tumors and normal subjects(P<0.01). (2) The serum uPA and uPAR levels increased by the increase of surgical-pathological stage and the decrease of histological grade (P<0.01). More uPA and uPAR were ensured in the serum of patients with lymph and/or omentum metastasis than not (P<0.01). (3) The positive rate measured by the combination of serum uPA,uPAR and CA125 were higher than those measured by the detection of CA125 alone(P<0.05).Conclusions The increase of serum uPA and uPAR in the ovarian cancer has relation to the development and metastasis of it. The combined detection of serum uPA,uPAR and CA125 might have a more important clinical value to the clinical diagnosis of ovarian cancers.