Analysis On The Detection And Antimicrobial Resistance Of ESBLs-producing K. Pneumoniae Isolated From Patients In XinJiang Urumqi District

Objective: To analysis the detection rates and antimicrobial resistance of extended-spectrumβ-lactamases (ESBLs)-producing K.pneumoniae isolated from patients in XinJiang district, and provides reference for the rational use of antimicrobial agents in clinic. Methods: The VITEK TWO automatic microorganism analyzing system was used to identify the strains and their drug susceptibility. Double disk synergy test was adopted in the strains with extended spectrumβ-lactamases (ESBLs). Retrospective studies were applied to analyze the drug resistance pattern of the clinical isolates of K.pneumoniae in The first affiliated hospital of XinJiang medical university. Results:391 strains of K.pneumoniae were isolated, the total positive rate of ESBLs was 42.71 %. As to ESBLs-producing strains of K.pneumoniae, the resistant ratio to penicillin was the highest, to ampicillin was up to 100%; the resistant ratio to imipenem was the lowest. It also has higher sensitivity to meropenem, piperacillin/tazobactam and cefoperazone/sulbactam. These strains also showed multiple resistances to aminoglycosides, fluoroquinolones and sulfonamides. Conclusions:K.pneumoniae have different levels of the drug resistance and the multi-drug resistant strains ratio and the positive rate are high, It has high resistance to most antimicrobial agents. Imipenem andβ-lactamases inhibitors could be used to control its infection.