| ObjectiveTo investigate the infection status, immune state and immunization changes of HBV for children prior to and after the HB vaccine was subsumed into the planning immunization in children in Chonging.MethodsHBV Serology markers detected by ELISA were investigated retrospectively in the children under 18 years old who were not HB patients or AcS in Children's Hospital of Chongqing Medical University from 1989 to 2009. According to age,HBVM were divided into≤28 d group, 1~6m group ,7~12m group,1~3y group,4~ 6y group,7~10y group and 11~18y group.Results1. The sero-epidemiological HBV serology markers for children in Chongqing from 1989 to 2009:In Chongqing, the changes of HBV serology markers in recent 21 years were statistically significant. The positive rate of HBsAg and/or HBeAg under 18 years old dropped gradually from 16.3% in 1989 to 1.4% in 2009. The positive rate of children with HBsAg,HBeAg and anti-HBc dropped from 12.8% to 1.1%, and the positive rate of children with HBsAg,anti-HBe and anti-HBc dropped from 3.6% to 0.3%. The positive rate of children with anti-HBe and/or anti-HBc dropped from 8.7% to 5.0%. On the other hand, the positive rate of anti-HBs increased from 4.3% in 1989 to 51.2% in 2009. 2. The sero-epidemiological HBV serology markers for children in Chongqing in 2009(1) In Chongqing, the positive rate of HBsAg was 1.4% (301/21473) for children in 2009. The positive rate of HBsAg, HBeAg and anti-HBc was 1.1% and the positive rate of HBsAg, anti-HBe and anti-HBc was 0.3%. The positive rate of anti-HBs was 51.2%(10990/21473). The positive rate of anti-HBe and/or anti-HBc was 7.0% (1501/21473). The negative rate of HBV serologic markers(HBVM) was 40.4%(8681/21473).(2)The positive rate of HBsAg and/or HBeAg in≤28 d group, 1~6m group ,7~12m group,1~3y group,4~ 6y group,7~10y group and 11~18y group were 1.9%, 0.7%, 0.9%, 0.5%, 1.0%, 2.1% and 4.9%, respectively. It was highest in 11~18 y (P<0.01). It was significantly higher in≤28d group than that in groups of 1~6m ,7~12m,1~3y and 4~6 y. And as the increasing age after 28d, the positive rate of HBsAg was increasing gradually(χ2=63.625,P<0.01).(3)The positive rate of anti-HBs in≤28 d group, 1~6m group ,7~12m group,1~3y group,4~ 6y group,7~10y group and 11~18y group were 32.8%, 49.7%, 79.3%,61.6%, 47.1%, 43.8% and 36.7%.It was the highest in 7~12 m group (P<0.01). It was significantly lower in≤28d group and 11~18y group than those in other groups(P<0.01). And as the increasing age after 7 months, it was decreasing gradually(χ2=949.22,P<0.01).(4)The positive rate of anti-HBe and/or anti-HBc in≤28 d group, 1~6m group ,7~12m group,1~3y group,4~ 6y group,7~10y group and 11~18y group were 29.5%, 16.8%, 5.0%, 1.6%, 1.0%, 1.9% and 5.7%. It was rates for the children of≤28 d and 1~6 m were significantly higher than other groups (P<0.01). In≤28 d group, 1~6 m group ,7~12m group ,it was decreasing gradually(χ2=983.12,P<0.01). (5)The rate of negative of HBVM in≤28 d group, 1~6m group ,7~12m group,1~3y group,4~ 6y group,7~10y group and 11~18y group were 35.8%, 32.8%, 14.9%, 36.3%, 50.9%, 52.2% and 52.7%, respectively.It was the highest in 7~12m group (P<0.01). And it was significantly higher in 4~6 y group ,7~10 y and 11 ~18 y were higher than≤28d, 1~6m, and1~3 y (P<0.01).Conclusions1. As HB vaccine was subsumed into the planning immunization, the infection rate of HBV under 18 years old in Chongqing has dropped gradually from 16.3% in 1989 to 1.4% in 2009.The positive rate of anti-HBs increased from 4.3% in 1989 to 51.2% in 2009.2.In 2009,the infection rate of children in Chongqing was 1.4%,lower than that of common crowds in the whole country in 2005.The positive rate of anti-HBs was 51.2%,higher than that of common crowds in the whole country in 2005.The positive rate of anti-HBs for the infants in Chongqing of 7~ 12 months old was the highest,but the rates of the newborns and the children for the puberty were lower.As the increasing age,the the positive rate of anti-HBs was decreasing gradually.The infection rate of children in Chongqing for the puberty was the highest,and as the increasing age,the infection rate was increasing gradually.The positive rate of HBsAg and/or HBeAg for newborns,especially anti-HBe and/or anti-HBc,was high.The newborns should be followed up.
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