Study Of Correlations Among Plasma CHEMERIN And Adipose Triglyceride Lipase Revelant Factors In Newly Diagnosed Type 2 Diabetic Patients With Hypertension.

Objective To investigate the changes of plasma Chemerin and adipose triglyceride lipase (ATGL) levels and the relationship between plasma Chemerin, ATGL levels and blood pressure, waist hip ratio (WHR), blood lipids, blood glucose,plasma insulin levels as well as other factors in newly diagnosed type 2 diabetic patients with hypertension. Methods Plasma Chemerin and ATGL levels were assayed byELISA in the type 2 diabetes mellitus (T2DM), type 2 diabetic patients with hypertension(T2DMH) and normal controls(NGT).The relationship between plasma Chemerin, ATGL levels and blood pressure, body mass index(BMI),WHR,HOMA-insulin resistance index(HOMA-IR),blood lipids, blood glucose, insulin and FFA were also analyzed.Results Plasma Chemerin level in T2DMH was significantly increased compared with T2DM and NGT[(74.6±6.4 vs. 68.6±12.5 and 62.1±19.3)μg/L,both P<0.01]. Plasma Chemerin levels correlated positively with age, body weight, waist circumference, hip circumference, Diastolic blood pressure(DBP), Visceral fat%(FAT%), body mass index(BMI), WHR, Triglyeride(TG), Free fatty acids(FFA), Fasting plasma glucose(FPG), 2h Plasma glucose after glucose load(2hPG), Fasting plasma insulin(FINS), 2h Plasma insulin after glucose load(2hPINS), HOMA-IR, Glycosylated hemoglobin A1C (HbA1C()r=0.20, 0.25, 0.33, 0.20, 0.27, 0.30, 0.34, 0.24, 0.25, 0.16, 0.17, 0.21, 0.18, 0.21, 0.21, 0.19 , P<0.01 and P<0.05).Multiple regression analysis showed that waist circumference, DBP, 2hPINS, HbA1C were independent related factors influencing plasma Chemerin levels.Plasma ATGL levels in T2DMH were significantly increased compared with T2DM[(78.3±23.5 vs. 65.1±22.8)μg/L,P<0.01], but no difference between T2DMH and NGT. Plasma ATGL levels correlated positively with Total cholesterol(TC) and High-density lipoprotein cholesterol(HDL-C) (r=0.17, r=0.16, both P<0.05). Multiple regression analysis showed that HOMA-IR, TC and DBP were independent related factors influencing plasma ATGL levels.Conclusion The changes of Chemerin and ATGL levels are associated with glucose and lipid metabolism and blood pressure, and it may contribute, in part, to the pathogenesis of insulin resistance and hypertension.