A Study Of The Correlation Between Early Renal Insufficiency And Severity Of Coronary Artery Stenosis At Xinjiang

Background and objective: Cardiovascular diseases is such a kind of disease which is severely harmful to public health and influences national economy, and is the main death course of end-stage renal disease. Lots of research has authenticated the correlation between chronic kidney disease and cardiovascular disease, but less study and report refers to the correlation between early renal insufficiency and cardiovascular disease. Recently years has found mild renal insufficiency can affect the procession and even predict the prognosis of cardiovascular disease. This article discusses the correlation between early renal insufficiency and the extent of stenosis of patients with coronary artery stenosis at xinjiang. Methods: 1393 cases were selected by estimated glomerular filtration rate with MDRD formulation to patients plan to underwent coronary angiography, whose estimated glomerular filtration rate exceed or equal to 30ml/min and coronary angiography evidenced coronary artery stenosis. Standard of K/DOQI by NKF was chosen as the criterion of chronic renal insufficiency, then divided them into three groups: normal renal function group, mild renal insufficiency group and moderate renal insufficiency groups, then discuss the correlation between early renal insufficiency and coronary artery stenosis through explore the association between the levels of estimated glomerular filtration rate and Gensini score. Results:No statistical significance was found in type and quantity in stenotic coronary arteries (P>0.05). Gensini score in mild renal insufficiency group and moderate renal insufficiency group is higher than normal renal function group (P<0.05), the female percentage is higher than normal renal function group(P<0.05); the percentage of smoker in moderate renal insufficiency group is lower than normal function group and mild renal insufficiency group(P<0.05). After compensating Confounding Factors, estimated glomerular filtration rate was negatively correlated with the extent of coronary artery stenosis(r=-0.058, P=0.03). Conclusions:1. Early renal insufficiency is not correlated with type and quantity in stenotic coronary arteries. 2. Female is a risk factor of coronary artery stenosis of early renal insufficiency patients. 3. Early renal Insufficiency is an independent risk factor of coronary artery stenosis, and estimated glomerular filtration rate was negatively correlated with coronary artery stenosis.