Pingxiao Capsule Combined With Chemotherapy For The Treatment Of Advanced Colorectal Cancer

Objective:To observe the effect and toxicity of the regimen of Pingxiao capsule combined with chemotherapy scheme of FOLFIRI for the treatment of advanced colorectal Cancer. Methods:Choosing the patients be hospitalized in our hospital between May,2008 and February,2010. Pingxiao capsule plus chemotherapy scheme of FOLFIRI was applied to treat 33 cases of advanced colorectal Cancer and choosing 30 patients for the only chemotherapy scheme of FOLFIRI. chemotherapy scheme of FOLFIRI include:CPT-11 150mg/m2 and 0.9% NaCl 250 mL ivgtt d1 5-FU 400 mg/m2 iv bolus,Following 5-FU 600 mg/m2 ivgtt 22h d1,d2;CF 200 mg/m2 and 5% GS 250mL ivgtt 2h d1,d2;two weeks as one cycle,efficacy and toxicity were evaluated at three cycles. When beginning the chemotherapy scheme of FOLFIRI,the group of curing patients take the medicine of Pingxiao capsule until the treatment being end. In front and behind,to observe the situation of the,appetite,extent of pain and tiring,the target of liver and kidney function,blood routine,ECG. Results:After two periods of treatment,the subjective symptoms,KPS,weights,the tumor mark(CEA)were significantly improved in the treated group,better than in the control one. In the sides of curative effect and quality of living,even the degree of alimentary canal side-effect and hematology toxicity in treatment group were better than the control group,P<0.05. But there was no difference between two groups on the size of focus,the toxicity occurent rate and toxic degree ware slighter in the treated group than in the control one,P>0.05.Conclusion:Pingxiao capsule combined with chemotherapy for the treatment of advanced colorectal Cancer can alleviate the alimentary cancal side-effect and hematology toxicity of chemotherapy drug in treating gastric cardia carcinoma.In all,it is effective and tolerable in advanced colorectal cancer. It is good for generalizing.