The Risk Factors Clinic Study Of Atherosclerosis In Early-metaphase Chronic Kidney Disease

Objective: To explore the influential factors of atherosclerosis in patients with chronic kidney disease. Methods: A retrospective study was conducted with 217 Chronic kidney disease patients in 1~4 stage. Then to analyze the relationship between carotid intimia-media thickness, carotid arteries atheromatous plaques and sex, age, Body Mass Index(BMI), systolic pressure(SBP), diastolic pressure(DBP), fibrinogen(Fg), total cholesterol(TC),triglycerides(TG),low-densit lipoprotein cholesterol(LDL),high-density lipoprotein cholesterol(HDL), fasting plasma glucose(FPG), blood uric acid(UA), serum phosphorus(Ph), the cross product of serum phosphorus and serum calcium(Ca×Ph) and evaluate Glomerular Filtration Rate(eGFR); Pearson or Spearman correlation analysis, multiple logistic regression analysis were applied to evaluate the statistical significance in this study. Results: Correlation analysis showed that intimia-media thickness is had positive correlation with Age, SBP, Fg, FPG, UA, Ph and negative correlation with eGFR; carotid arteries atheromatous plaques is had positive correlation with Age, Fg, FPG, UA, Ph and negative correlation with eGFR; multiple logistic regression analysis showed that intimia-media thickness is had positive correlation with chronic kidney disease, UA, Fg, Age and SBP (P<0. 05, 0. 01); carotid arteries atheromatous plaques is had positive correlation with chronic kidney disease, Fg and Age (P<0. 05, 0. 01). Conclusion: eGFR, UA, Fg, SBP and Age are the independent risk factors of atherosclerosis in early metaphase chronic kidney disease patients.It should be prevented promptly for cardiovascular diseases complication of chronic kidney disease patients.