Evaluation Of Myocardial Perfusion Using Color-encoded Parametric Quantification In Patients With Acute Myocardial Infarction

Object: This study aimed at investigating the application of parametric quantification (PQ) on myocardial perfusion evaluation in patients with myocardial infarction (MI). Methods: Real-time myocardial contrast echocardiography (MCE) was performed on 36 MI patients pre- and post-percutaneous coronary intervention (PCI). The myocardial segments in these patients were divided into 4 groups according to thrombolysis in myocardial infarction trial (TIMI) grade of coronary artery. Myocardial perfusion was assessed on each segment by the following. methods: 1) qualitative MCE with parametric image (PI) perfusion score, 2) quantitative MCE with myocardial perfusion parameters (A,βand A×β). Results: Before PCI, the qualitative analysis showed that, 1) the PI perfusion score correlated with the TIMI grade, 2) the consistency between PI perfusion score and TIMI grade was well (Kappa=0.695, P=0.000) on diagnosing myocardial perfusion abnormality. The quantitative analysis showed that Before PCI, the parameters significantly differed among the 4 groups(P<0.05). After PCI, the PI perfusion score and parameters of segments supplied by infarct-related artery (IRA) of each group improved, but there were no differences in TIMI grad(eP>0.05). 3) Still the parameters increased linearly with the TIMI grading. Conclusions: Comparing to the TIMI grade, the technique of PQ supplies necessary evidence in evaluating the establishing of collateral circulation of coronary artery and screening patients for revascularization before PCI. The TIMI grade reached 3 after PCI, while both of the qualitative and quantitative analysis detected abnormal of regional myocardial perfusion. PQ provides a beneficial supplement to provide.