The Analysis Of Prognostic Factors For Survival After Curative Resection Of Hepatocellular Carcinoma Accompanied Cirrhosis

Objective: To analyze the prognostic factors affecting survival after curative resec -tion of hepatocellular carcinoma (HCC) accompanied cirrhosis . Methods: It was retrosp -ectively analyzed that the clinical and pathologic data of 103 Patients with HCC accomp -anyied cirrhosis who underwent curative hepatectomy in the First Affiliated Hospital of Xin jiang Medical University from January 2002 to January 2009 , followed up to January 2010. The prognostic factors affecting survival were studied by univariate and multivariate analysis. Results:The 1-,2-,3-,5-year disease-free survival rates were 47.0%,35.0%,28.0 % and 13.0 %, respectively. The 1-,2-,3-,5-year cumulative survival rates were 60.0%,40.0 %,27.0% and 11.0%, respectively. Univariate analysis showed that Child-Pugh class , degree of accompanying cirrhosis , Preoperative alphafetoprotein (AFP) level, tumor size , number of tumors , tumor thrombus , satellite nodule , tumor capsule, necrosis, pathologic -al grade, operation time length,intraoperative bleeding volume, blood transfusion volume, resection extent, hepatic hilum interruption, Anatomical hepatectomy, postoperative transcatheter hepatic arterial chemoembolization (TACE) were significant prognostic factors. The use of Cox s multivariate proportional hazard model indicated that significant prognostic factors for disease-free survival and cumulative survival rates were degree of accompanying cirrhosis, satellite nodule, tumor capsule, blood transfusion, postoperative TACE. Conclusion: Accompanying mild cirrhosis , without satellite nodule and tumor capsule infiltrate, blood transfusion less than 4U and postoperative TACE are premise of good prognosis of patient s with HCC accompanying cirrhosis after curative hepatectomy. preoperative precise appraisal, shortening operation time length,Insisting on the principle of precise hepatectomy, remaining maximanal hepatic tissue, avoiding blood transfusion and postoperative TACE which strongly improved prognosis in HCC accompanying cirrhosis after curative hepatectomy.