The Expression And Significance Of NF-κB And Survivin In Transitional Cell Carcinoma Of Bladder

Objective:To evaluate the immunohistochemistry expressions of NF-κB and Survivin in the transitional cell carcinoma of bladder and the relationship between the expressions of NF-κB and Survivin and the age,gender,pathological stage,grade,lymph node metastasis,and recurrence of bladder cancer.Methods: Immunohistochemical S-P staining method was adopted for detecting the expression of NF-κB p65 and Survivin in 60 cases of transitional cell carcinoma of bladder and 10 cases of adjacent normal tissues, The immunoassay results were evaluated in relation to age,gender,tumor stage,grade,lymph node metastasis,and recrudesce.Results:1.In the 60 bladder cancers, 75%(45/60) was positive for NF-κB p65 expression. 10% (1/10) was positive for NF-κB p65 expression in all bladder benign lesions. The expression of NF-κBp65 was well correlated with tumor grades,stage,and lymph node metastasis(P<0.05), but not correlated with age,gender, recurrence (P>0.05).2.In the 60 bladder cancers, 71.7%(43/60) was positive for Survivin expression. 20% (2/10) was positive for Survivin expression in all bladder benign lesions. Survivin expression significantly correlated with tumor grades,and recurrence (P<0.05), but not correlated with age,gender, stage,and lymph node metastasis (P>0.05).3. There was a significant positive correlation between expression of NF-κB p65 and Survivin in bladder cancer(r=0.320,P<0.05).Conclusions:1 NF-κB and Survivin were over expressed in transitional cell carcinoma of bladder,and there play an important role in tumorigenesis .2 The expression of NF-κBp65 was well correlated with tumor grades,stage,and lymph node metastasis, but not correlated with age,gender, recurrence. Survivin expression significantly correlated with tumor grades,and recurrence, but not correlated with age,gender, stage,and lymph node metastasis.3 There was a significant positive correlation between expression of NF-κB p65 and Survivin in bladder cancer, high expression of NF-κB might be a cause of regulating the Survivin,and play an important role in tumorigenesis and progression。...