The Correlation Study Between A Variety Of Factors And Traditional Chinese Drug And Postherpetic Neuralgia

Objective:1.By investigating epidemiology about clinical factors of herpes zoster,to explore the correlation factors about developing postherpetic neuralgia,to provide the help in preventing PHN.2. Seek the correlation between therapy with syndrome differentiation and PHN. Antivivals were divided 2 groups,whether or not exposure to chinese medicine, comparing the incidence of PHN.In the hope that if could bring a more positive impact on PHN by therapy with syndrome differentiation in acute stage.Methods:Clinical data of the 80 outpatient of herpes zoster 2009.5-2009.12 in our hospital were collected including age,sex,Prodrome pain,clinical characteristics of HZ,part of rash,settings time of initial treatment,TCM syndrome type in acute stage,ways of the therapy,accompanied systemic diseases,exposure of immunity-inhibitors,and following-up information for 3 months from 80 patients.All available data are dealt with univariate by SPSS for windows 17.0.Postherpetic neuralgia is defined as pain or and allodynia, itching,numbness in the zoster dermatome more than 1 months after healed rash.Severity of Postherpetic neuralgia was measured by VAS,while the-6-point behavioral rating scale(RBS-s)was used in following up patients. Results:1. Epidemiologic data:Of the 80 patients,37 male and 43 female,the mean age 54.3846±16.5173 years(range from 18-81).22 patients(28.21% in 78) developed PHN,the mean age of patients who developed PHN is 64.1818±8.8636 years.2. Age and gender:78 patients were divided into four groups by age,the incidence of PHN is significantly different(χ2=14.86,P<0.01).There is significant difference between male and female(χ2=4.3956,0.01 0.05).7. Different ways of therapy in acute herpes zoster:Antivirals were divided different 2 groups,whether or not exposure to chinese medicine,comparing the incidence of PHN,χ2-test showing there is significantly different between them(χ2=4.16, P<0.05).8.Systemic diseases and PHN:Patients with diabetic mellitus or connective tissue disease compared other systemic diseases there is significantly different in the incidence of PHN.ConClusions:The risk of PHN increases progressively with age;in our studies,the prevalence of PHN is 28.21%,the mean age of patients who developed PHN is 64.1818±8.8636 years.Individuals aged 50 years or older have higher prevalence of PHN relative to individuals younger than 50 years.1.Prodromal symptoms is not associated with higher prevalence of PHN.2.Distribution of the rash is not associated with PHN,the clinical type is relative to PHN,the more severity of rash,the more possibility of PHN. 3. The time of initial treatment is critical to prevent PHN, the earlier to receive therapy,the lower the incidence of PHN. Chinese medicine could reduce the prevalence of PHN.4.Diabetic mellitus and connective tissue disease seemed that they are higher risks of PHN.5.there is no significantly different between syndrome type of chinese medicines and PHN.6. there is a more positive impact on PHN by therapy with syndrome differentiation in acute stage.