| "Pathogenesis factor" is Professor Zhou Zhongying in the long-term clinical practice, in succession based on the theory of traditional Chinese medicine, Chinese medicine combined with new era under new problems facing the proposed new academic thinking, is an innovative theory of pathogenesis. This study was a "prime Pathogenesis" research methods to the preliminary study in Primary Sjogren's syndrome or acute and chronic relief of the distribution at different time points the evolution of law, based Syndrome Pathogenesis of research more the basis of objective evidence-based medicine.Theory, first summarized the current research Sjogren's syndrome profile Western focus of Western medicine on the pathogenesis of this disease and the resulting profile and the lack of treatment limitations. The Chinese medicine in improving the symptoms of disease significantly delayed the advantages of Western medicine for the disease in the current clinical research face difficult circumstances, to strengthen the disease-based medicine clinical research to guide clinical treatment to improve further improve the efficacy of urgency. The current modernization of Chinese medicine in Chinese medicine research is also facing a series of questions, summed up by the system review of the literature in recent years, Chinese research results and suggested some new era for Chinese medicine research ideas and methods of shallow knowledge. "Pathogenesis factor" is a new era of academic thinking to solve problems facing the development of Chinese medicine is a new way, for the pathogenesis of Sjogren's syndrome to carry out the basis for studying the evolution of the law.Clinical studies,85 cases were divided by seven time points of field epidemiological investigation, analysis of eight factors Pathogenesis distribution, and clip, composite, evolution and pathogenesis of syndrome elements and the age, sex, season, past history, personal life history and correlation with laboratory indexes.Statistical analysis:acute onset or exacerbation of 45 cases, a single factor Pathogenesis newly diagnosed with fire, heat, blood stasis, mainly dry, accounting for 60.0%, 53.3%,48.9%, 48.9%, one year after the pathogenesis card element to yin deficiency, qi deficiency, blood deficiency, mainly dry, respectively 86.7%,48.9%,33.3%,31.1%; and folders complex factors Pathogenesis diagnosed with stasis fire, hot, hot stasis mainly accounted for first visit 42.2%, 42.2%,28.9%, one year after the Qi and Yin deficiency, dry, and Yin, Yin blood deficiency, yin deficiency and blood stasis mainly accounted for 44.4%,31.1%,28.9%,28.9%. Newly diagnosed by the correlation coefficient of fire and blood stasis, fire and heat, dryness and thermal correlation.40 cases of chronic remission, Pathogenesis, known for a single deficiency, Yin deficiency, dry mainly accounted for 70.0%,62.5%,55.0% through seven time points and no significant changes, and folder Pathogenesis known for complex and Yin deficiency, dry and qi deficiency, yin deficiency mainly dry and accounted for 47.5%,42.5%,42.5% seven time points throughout the seven no change. Pathogenesis by statistical analysis of factors related to age, sex, season, personal history, family history was no significant correlation. Pathogenesis factors and laboratory indicators:RF and heat and significantly correlated with blood stasis; IgG with fire and heat are significantly correlated; ANA and yin, fire, blood stasis, there is significant correlation.Conclusion:Pathogenesis single element of fire, heat, blood stasis, and stasis and folders complex pathogenesis of fire, hot, hot is the initial issuance of stasis or acute exacerbation of the main factors Pathogenesis and have to Qi, Yin, and Yin deficiency conversion trend. Pathogenesis single factor deficiency, Yin deficiency, dry and complex and folders Pathogenesis factors Qi and Yin deficiency, dry and yin deficiency, qi deficiency in chronic dryness and ease Pathogenesis of the main factors, and no runs through seven time points significant change.
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