| Atherosclerosis (Atherosclerosis, AS) serious harm to human health, common diseases. Symptoms of the disease or disability, fatal consequences occur after more than 40 years of age, men in women with early onset. Common in Europe and the United States developed countries, morbidity and mortality in developing countries is also increasing. In China, the disease more common than in Europe and America, but the increasing trend in recent years, so atherosclerosis in the pathogenesis and anti-atherosclerosis drugs has increasingly become a research hotspot. Institute of atherosclerosis animal model used in animal species used in many different animal models have different advantages and disadvantages, choose a suitable model for the mechanism of atherosclerosis research and drug intervention is necessary.AS vulnerable plaque has obvious morphological features:thin fibrous cap, and inflammatory cell infiltration and lipid accumulation. AS of early lesions can be seen within the monocyte/macrophage accumulation, inflammatory cells such gathering in the plaques is one of the reasons leading to plaque rupture, through the production of cytokines, chemical factors for the development of AS.China's independently developed Xuezhikang statins, has been widely used in secondary prevention of coronary heart disease. Xuezhikang is refined by the Chinese red yeast, is HMG-CoA reductase inhibitor class of lipid lowering drugs, the main ingredient is lovastatin class, which includes 13 kinds of natural ingredients combined statin and a variety of unsaturated fatty acids and amino acids, can reduce blood fat, improve endothelial function.1. The establishment of rabbit atherosclerotic vulnerable plaque pathology model, application of drug to trigger unstable plaque rupture.2. Xuezhikang intervention model observed in rabbits the role of vulnerable plaque rupture, through the pathological model of blood lipid levels, high sensitivity C-reactive protein (hs-CRP), interleukin -6 (IL-6), nuclear factor-κB (NF-kB), P53 gene and other tests related to the mechanism of Xuezhikang.1.30 adult rabbits were randomly divided into 2 groups:normal diet group or control group (10), experimental group (20). Control group only received normal diet rabbits; experimental rabbits with balloon injury of abdominal aorta+high cholesterol diet (1% cholesterol) diet for 12 weeks,10 weeks after the transfer via the catheter to the site of the lumen in injected p53 recombinant vector, the rabbits were killed before the 24h and 48h for the two drugs trigger a: Rabbits injected venom of Russell's frog 0.15mg/kg,30 min after venous injection of histamine 0.02mg/kg, to promote experimental plaque rupture.2. The model was successful rabbits were randomly divided into model group, treatment group 2 group. Treatment of rabbits fed beginning at 4 weeks, given Xuezhikang (60mg/kg, drug concentration:12mg/ml), for 8 weeks to the end of experiment. Lipid levels observed in rabbits in each group, hs-CRP, IL-6, NF-kB, P53 gene and other changes, and light microscope morphology, electron microscope electron microscope.1. Light and electron microscopy showed pathological rabbit model of abdominal aortic atherosclerotic plaques produced success.2. Xuezhikang treatment group compared with model group, rabbits total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), IL-6, hs-CRP levels decreased, the difference statistical significance; NF-kB expression was significantly reduced local, P53-positive cells decreased significantly.1. The use of balloon injury in the abdominal aorta+high-fat diet+drugs trigger the method can be established atherosclerotic rabbit model of vulnerable plaque pathology.2. Xuezhikang model rabbits significantly reduced IL-6, hs-CRP, NF-kB, P53 expression, can significantly reduce the model of rabbit serum TC, TG, LDL-C levels, with a certain degree of intervention model Rabbits atherosclerosis the role of vulnerable plaque rupture.
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