Study On The Clinical Features And Its Correlation With Urinary Albumin Excretion Rate Of Patients With Polycystic Ovary Syndrome

To evaluate urinary albumin excretion rate(UAER) in women with polycystic ovarian syndrome (PCOS) in relation to their clinical,endocrine,and metabolic indexes.Based on ESHRE/ASRM criteria, we collected 100 patients with polycystic ovary syndrome and 30 healthy women as control. Using case-control study on them with clinical features, serum sex hormone levels,urinary albumin excretion rate,metabolic indicators and the correlations between them.1.The clinical featuers are summerized as follows:oligomenorrhea take up 63%,secondary-amenorrhea take up 12%, menstrual disorder take up 13%, hyerandrogenism take up 59%,69% PCOS with LH/FSH≥2,37%PCOS with LH/FSH≥3,44% patients have acne,19% patients are hirsutism,78% show polycystic ovary one or both side toword B-ultrasound,25% with the ovarian volume≥10ml,43% patients are obesity (BMI≥25kg/m2),38% patients are central obesity (WHR≥0.85),49% have insulin resistance,17% have acanthosis nigricans,36% have metabolic syndrome.2.Among them,typeⅠPCOS (PCO/HA/IM)take up 40%, typeⅡPCOS (PCO/HA) take up 9%, typeⅢPCOS (PCO/IM) take up 36%, typeⅣPCOS (HA/IM) take up 15%.3. Adolesent patients (age≤19 years) take up 12%, reproductive age patients take up 88%,41 cases of patients with infertility or secondary infertility, occupied 46.59% of the reproductive age patients.4. The menstrual cycle,BMI, WHR, hirsutism score, ovarian volume, antral follicle number, T, A2, DHEA-S, FTI, LH, LH/FSH, FPG,FINS,TG,TC,HOMA-IR of PCOS are higher than healthy control group.SHBG, HDL are lower than the control group, the differences are statistically significant (P<0.05).5.59 PCOS patients have UAER testing, the incidence of microalbuminuria in this group is 8.47%-13.6%, in the control group, the incidence of microalbuminuria is 6.67%. There is no statistical difference between the two groups (P>0.05)6. The urinary albumin concentration and urinary albumin/creatinine rate(ACR) of the PCOS group are higher than the control group, the difference is statistically significant (P<0.05).7. Pearson correlation analysis indicated that, ACR positively correlate with diastolic blood pressure, BMI,WHR,TG,HOMA-IR, and negatively correlate with HDL (P<0.05). Multiple linear stepwise regression analysis showed that,in the P< 0.05 level,diastolic blood pressure and HOMA-IR into the equation, and as the independent risk factors of UAER in patients with PCOS.1. PCOS patients concentrated in the age of 20 to 35 years old.2. ESHRE/ASRM criteria is mainly suitable for the PCOS patients in our region. PCOS patients with LH/FSH≥2 take up a great proportion,so LH/FSH≥2 can be a secondary diagnosis for the PCOS in this area.3. TypeⅠand typeⅢare more, which is different from other foreign and domestic research.4. The incidence of microalbuminuria in PCOS is 8.47%-13.6%.5. The urinary albumin concentration and urinary albumin/creatinine ratio (ACR) in PCOS are higer than the control group, suggesting PCOS have higher UAER trend.6. The UAER in PCOS has relation with some clinical features, among them HOMR-IR and diastolic blood pressure as the independent risk factor of UAER...