Study On The Relationship Of Adiponectin And Neonatal Bone Mineral Density

ObjectiveThe objective of the study was to examining the relationship of adiponectin and bone mineral density of early preterm infants,discussing the possible mechanism of their susceptibility to osteoporosis in adulthood.Methods1.Subjects and experimental groups:data of all the neonates within the first week of life hospitalized in the neonatal intensive care unit (NICU) of department of neonatology of the second xiangya hospital of central south university during the period from March 1 to September 31, 2009 were recorded for statistical analysis, subjects who were small or large for gestational age, have central nervous system diseases, have neuromuscular disorders, receive hormone therapy, have congenital malformations, the mother with severe pregnancy complications were excluded. All Subjects were divided into three groups:1)preterm infants group:31-34 weeks of gestational age;2) near-term infants group:34-37 weeks of gestational age;3)term infants group:37-42 weeks of gestational age.2.Anthropometric measurements of newborns:birth weight, body length, head circumference, leg length and skinfold thickness of biceps(BS), triceps, subscapular and suprailiac was wright down, ponder index was calculated by [PI=100×weight(g)/body length(cm)3]to evaluate nutritional status of neonatal infants,percent of total body fat mass was calculated by F%=0.8848×SFT4+0.022.3.Measurements of bone mineral density:an omnisense ultrasound bone sonometer was applied to measure speed of sound of tibia in preterm infants and term infants.4.Adiponectin:adiponectin were detected by ELISA.Results1.The median of tibia SOS in preterm infants was significantly lower compared to that of near full-term infants;and it was also lower than that of term infants,the median of tibia SOS in near full-term infants was also lower than that of term infants,there was significant difference between them statistically.2.The median of adiponectin in preterm infants was significantly lower compared to that of near full-term infants,it was also lower than that of term infants, the median of serum adiponectin in near full-term infants was significantly lower compared to that of term infants, there was significant difference between them statistically.3.There were significant positive correlations between adiponectin and tibia SOS of preterm infants, which remained significantly after adjustment for gestational age, body length, body fat mass;according to the result of multivariate linear stepwise regression analysis, adiponectin and birth weight was independent predictor of tibia SOS of preterm infants.There were significant positive correlations between adiponectin and tibia SOS of term infants, which remained significantly after adjustment for gestational age, body length, body fat mass;according to the result of multivariate linear stepwise regression analysis, adiponectin and gestation age were independent predictors of tibia SOS of term infants.Conclusion1.Bone development of preterm infants lags behind to that of term infants.2.Adiponectin in serum of preterm infants was lower than that of term infants, adiponectin could affect neonatal bone development.3.There were significant positive correlations between adiponectin and tibia SOS of preterm infants, and it was independent predictor of tibia SOS of preterm infants;lower adiponectin levels in preterm infants may be one possible mechanism of their susceptibility to osteoporosis in adulthood.