Diabetes And Cognitive Impairment

Objective :To investigatethe cognitive between diabetes and non diabetes with Montreal cognitive assessment, and then analyze those two groups of people with Magnetic Resonance Spectroscopy on brain hippocampus. So we can overview the effection between diabetes and non-diabetes on molecular level,furthe more to study how insulin secretion,drug treat effect cognition.Methods: chose 39 diabetes and 39 normal people as research object with the mach of sex,ges,ducation levels and so on. Then do MMSE ( mini mental state examination),AD,oCA test,rain hippocampus MRS.And also the diabetes will do C- peptide text,rug therapeutics conditions and so on.With all those evaluations and records,we do some sorting,rejecting the mismatch or exiter halfway.Make comparability analyses with the two group,MSE and HAD comparison analyses,oCA total score and each item comparison analyses. Do some data processing at brain hippocampus MRS,make some metabolins comparison analyses.Do the diabetes further grouping according to drug treatment condition and insulin secretion,and carry out MoCA and brain hippocampus MRS analyze,to evaluate cognition effected by drug treatment and insulin secretion function.Results:(1)There is no significant different in sex,ge,ducational level,AD between the cases and the control group,but MMSE score appearants polarization. The cases are lower than the control group in Vis-vacuity,enomination,alculation,bstract,ttention,anguage,elay reminiscence,direction location and total score. Among the total, there are significant lower than the control group such as Vis-vacuity,enomination,alculation,bstract,elay reminiscence and total score(p<0.01). there are some diversity between the cases and the control group at the hippocampus MRS in left Cho( p=.012<0.05),AA(p=.008<0.01),right Cho (p= .033<0.05),AA (p=.034<0.05),of all the above contents, left NAA apparent significantly different between the cases and the control group. (2)According to insulin secretion function take C-peptide 0.3 as breakthrough,and then to divide the diabetes insulin secretion normal group and insulin secretion abnormal group, then make comparison with MOCA and MRS those two group, we found that there is no different in sex,age,education level about those two group,but they are diversity in orientation force with MoCA, there is also no different in MRS. (3)According to drug treatment condition(non treatment,drug treatment,insulin treatment) we found that there is no significant difference.Maybe this outcome have something with the cases selection,quantity,selection offset and so on.Conclusion:there is a pristine cognition damage comparatively, and the cognition damage have something to do with blood glycometabolism and insulin secretion in diabetes, also it can reflected with implement MRS,we can found that there is abnormal metabolin in brain.