| Objective To evaluate the 64-slice spiral CT perfusion imaging in rabbits at one side of ureteral completed obstructed in different parts of lateral renal function, and explore the relationship between perfusion parameters and ureter delayed development time.Materials and methods 50 adult healthy New Zealand rabbits were randomly divided into two groups, the proximal group (25), ligated below the right ureteropelvic junction (ureteropelvic junction, UPJ); the remote group (25), t ligated below the right ureter 1/3 ligation, these two groups were divided into five sub-groups of five in accordance with obstruction after 2 days, 1 week, 2 weeks, 3 weeks and 4 weeks. Using Siemens Somatom Sensation 64-slice CT machine, all experimental animals underwent preoperative right kidney computed tomography perfusion imaging (CTPI), the raw data obtained of scaner transmitted to the workstation Syngo. Then all raw data were postprocessed via workstation by observers, trained to use the technology proficiently, with body perfusion software items in the Kidney, to get the perfusion images and the parameters. Take conventional delayed CT scan after perfusion. Record normal rabbit ureter development time. Modeling is successful, according to these groups, each sub-group take right kidney CTPI, to get the perfusion images and the parameters after post-processing. Take conventional delayed CT scan after perfusion. Record each sub-group obstruction development time of the end of ureteral obstruction. Use SPSS13.0 for Windows statistical software packages and Excel 2003 to analyze on various sets of data and compare the differences in renal perfusion parameters after obstruction. To explore the link between the perfusion imaging parameters and ureteral development time delay. Results⑴After model building, the BF, BV value of cortex and medulla in both proximal and distal group decline with the increased in obstruction (P <0.05), MTT values corresponding increase (P<0.05), development time increased with ureteral obstruction over time (P <0.05), the ureter will no longer develop after 3 weeks.⑵In 2 days and 2 weeks, the differences of cortex BF,BV, medulla BV, ureter imaging time between the proximal and remote groups were significant (P<0.05), MTT parameters were no significant difference (P>0.05); In 1 week, the differences of cortex BF,BV, medulla BF,BV, ureter imaging time between the proximal and remote groups were significant (P<0.05), MTT parameters were no significant difference(P>0.05); In 3 weeks and 4 weeks, the differences of cortex BF,BV, medulla BF,BV, MTT, ureter imaging time between the proximal and remote groups were not significant (P>0.05), the ureter will no longer develop.⑶The ureter imaging time of proximal group were less than the remote group, the differences were significant (P<0.05), the ureter will no longer develop in 3 weeks and 4 weeks.⑷The cortex and medulla perfusion parameters were correlated with ureter development time (P<0.05), in which, cortical BF is most high correlated. Linear regression equation of cortical BF(X) and ureter development time(Y) were, proximal group: Y? =642.794-6.732X. remote group: Y? =64.025-0.145X. When the cortical BF of proximal group down to 29.75% of normal, the cortical BF of distal group down to 29.34% of normal, the ureter will never develop anymore.Conclusion⑴64-slice spiral CT perfusion of kidney can reflect the ipsilateral renal blood flow of rabbit kidney with unilateral ureteral obstruction completely.⑵In early time, effection of proximal obstruction on renal blood flow was greater than remote obstruction.⑶There is a high correlation between renal cortex BF value and ureter development time, by measuring the renal cortex BF value, ureter development time could be predicted preliminarily.
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