Levels Of SIL-2Receptor And SICAM-1 In Cerebrospnial Fluid And Their Clinical Significance In Patients With Central Nervous System Infection

Objective To explore the changes f sIL-2R and sICAM-1 levels in CSF and their significance in patients with infection of central nervous system (CNS).Methods The levels of sIL-2R and sICAM-1 were determined by ELISA in acute-phase CSF of 25 patients with tuberculous meningitis(TBM),15 with Purulent Meningitis(PM) 25 with viral encephalitis(VM) and 20 normal subjects and a comparison was carried out between severe,mild group.Results The levels of sIL-2R and sICAM-1 in acute-phase CSF were higher in CNS infected groups than in control, the difference was significant(p<0.05); sIL-2R level higher in TBM group than in groups PM,VM, and sICAM-1 level higher in groups TBM,PM than in VM group, the difference was significant(p<0.05);levels of sIL-2R, sICAM-1 were higher significantly in severe group than in mild group(p<0.05).Conclusions sIL-2R and sICAM-1, involved in the pathological process of CNS infection,are related to the severity of CNS infection.may contribute to pathologic course in infection of central nervous system. The level of sIL-2R contributes to distinguishing TBM from PM and VM. The level of sICAM-1 in CSF may be of value in differenciating VM from PM and TBM.