The Correlations Of Perioperative Serum Catecholamines Concentration And Cytokines Level In Patients Undergoing Esophagecotomy

Objectives:To investigate the correlations of perioperative serum catecholamines and cytokines TNF-α,IL-6 level in patients undergoing esophagecotomy, and to imply that catecholamines play a key role in controlling inflammations.Methods:Twenty patients, who had no systemic diseases(ASA gradeⅠ～Ⅱ) and suffered from esophageal carcinoma, were scheduled for esophagecotomy under one-lung ventilation(OLV). Blood specimens were taken from radial artery at the time-points of before anesthesia(TO), before OLV(T1), OLV1h(T2), after lung dilated 1h(T3),4h(T4) and 24 h (T5) after the surgery, then the concentrations of E, NE, TNF-αand IL-6 were measured separately with ELISA method.Results:During perioperation, the serum concentrations of E, NE, TNF-αand IL-6 changed similarly, and increased significantly after T1, and peaked at T3, then decreased slowly, and the levels at T5 were still higher than that at T0(P<0.01). According to spearman correlation analysis, it demonstrated that there was a positive relationship between E and cytokines TNF-α(P<0.05), IL-6(P<0.05), and NE was also positively correlated with TNF-α(P<0.01) and IL-6(P<0.05).Conclusion:The esophagecotomy in OLV leads to a significant pro-inflammatory response and peaked at 1h after lung dilated. E and NE was positively correlated with TNF-αand IL-6. It implies that catecholamines may control pro-inflammatory effects through regulating the release of cytokines. This might be one of the possible mechanisms of systemic inflammatory response.