The Study On The Relationship Between Expression Of GDNF, GPC-1, MMP-9 And Perineural Invasion In Pancreatic Cancer

ObjectiveTo investigate the relationship between expression of glial cell derived neurotrophic factor (GDNF), glypican-1 (GPC-1), matrix metalloproteinase-9 (MMP-9) and perineural invasion and prognosis of pancreatic cancer.MethodsImmunohistochemical assessment of GDNF, GPC-1 and MMP-9 was performed for 62 cases of surgically resected pancreatic cancer to observe perineural invasion in pancreatic cancer after marking perineurium with S-100, and to analysis the relationship between expression of GDNF, GPC-1, MMP-9 and clinicopathologic parameters.Results(1)The over-expression of GDNF, GPC-1 and MMP-9 in pancreatic cancer tissue were significantly related to the perineural invasion (p< 0.05), but not related to the gender, age, tumor location, size or degree of differentiation.(2)The expression of GDNF, GPC-1 and MMP-9 in pancreatic cancer tissue were positively correlated with each other (r=0.724,0.592, 0.510, p<0.05).(3)The positive expression of GDNF, GPC-1 and MMP-9 in pancreatic cancer tissue were correlated with short survival time of patients after operation (p<0.05).Conclusion(1)GDNF, GPC-1 and MMP-9 may play important roles in the progression of perineural invasion of pancreatic cancer because the over-expression of GDNF, GPC-1 and MMP-9 were significantly related to perineural invasion in pancreatic cancer.(2)GDNF, GPC-1 and MMP-9 may play cooperative roles in the progression of perineural invasion because of their positively correlated expression in pancreatic cancer with perineural invasion.(3)GDNF, GPC-1 and MMP-9 may play important roles in prognosis because their positive expression may correlated with the short postoperative survival time in pancreatic cancer.