Study On The Correlation Between EGFR And Atherosclerosis In Non-dialysis Patients With Chronic Kidney Disease

Objective: To measure the pulse wave velocity(PWV) and ankle-brachial index (ABI) in patients with non-dialysis chronic kidney disease(CKD). To analysis the PWV and ABI as the assessment of the clinical significance of atherosclerosis.Method: 1.This is a cross-sectional study.118 inpatients with diagnosis of non-dialysis CKD (stage 1-5) were selected in our hospital from October 2008 to October 2009 . 2. Clinical data were recorded,including sex, age, height, weight, smoking status, blood pressure, fasting glucose, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), renal function. 3. eGFR was calculated. 4.baPWV and ABI values were determined. 5.24 hours urinary protein were detected. 6. SPSS 15.0 was used for statistical analysis.Results:1. According to eGFR level,a total of 118 patients were divided into 5 groups as CKD stage 1 group to CKD stage 5 group.2.There were significant differences in ABI value between 5 groups(F = 28.123,P <0.01). Compared with CKD stage 1 group, ABI values were significantly decreased in CKD stage 3 group (P <0.01),stage 4 group (P <0.01) and stage 5 group (P <0.01).There was no difference between CKD stage 1 group and stage 2 group (P >0.05). ABI value was significantly decreased with gradual decline of eGFR level (P<0.01)3.There were significant differences in PWV value between 5 groups(F = 141.759,P <0.01). Compared with CKD stage 1 group, PWV values were significantly increased in CKD stage 2 group (P <0.01), stage 3 group (P <0.01),stage 4 group (P <0.01) and stage 5 group (P <0.01). PWV value was significantly increased with gradual decline of eGFR level (P<0.01).4. Multiple regression analysis showed that age (P <0.01), diabetes (P <0.01), hypertension (P <0.01)and CKD stage(P <0.01) were risk factors for the ABI value . Age (p <0.01), low HDL (p <0.01)and CKD stage(p <0.01) were risk factors for the PWV value multiple regression analysis.Conclusion: Renal dysfunction was independent of other traditional atherosclerosis risk factors. Decline of eGFR was closely related with the degree of atherosclerotic lesions. ABI and PWV can be used as important clinical indicators of atherosclerosis in patients with CKD.