| In recent years, the nonlinear phenomena have more and more been recognized. As one of the most important nonlinear phenomenon in chemical systems, the oscillating chemical reactions have also been widely investigated. In this paper, L-lysine was determined in an alkaline system catalyzed by Cu(Ⅱ) and the perturbation of methionine on a Mn(II)-catalyzed system which glucose involved was also discussed. A new method for the determination of epinephrine by using non-equilibrium stationary state in the B-R oscillating chemical system was proposed.Chapter I: IntroductionThis part reviews the conditions arousing chemical oscillation behaviors and the classifications of chemical oscillating systems. The application of oscillating systems to analytical determination such as amino acids and drugs is also discussed. Finally, the perspective of chemical oscillation reactions is described simply.Chapter II: Determination of L-lysine by using NaSCN-CuSO4-H2O2 oscillating systemThis chapter studied the perturbation of L-lysine on NaSCN-CuSO4-H2O2 oscillating system. Results showed that a well linear relationship between the potential difference and the negative logarithm of concentration of L-lysine was obtained to be in the range of 1.5×10-61.3×10-4 mol/L with a lower detection limit of 7.5×10-7 mol/L. The correlation coefficient was 0.9976. Meanwhile, the possible perturbation mechanism was discussed in brief.Chapter III: Determination of L- and D-methionine by using a glucose-acetone-Mn(II)-KBrO3-H2SO4 double organic substrate oscillating systemAn approach that used a double organic substrate oscillating system of glucose-acetone-Mn(II)-KBrO3-H2SO4 to determine L- and D-methionine was made. The results showed that in the concentration ranges of 7.5×10-71.0×10-5 mol/L for L- methionine and 4.0×10-62.3×10-5 mol/L for D-methionine, respectively, the changes of the oscillating period were proportional to the negative logarithm of their concentrations. The effects of temperature and reaction components on the reaction were also studied in detail. The proposed method has been successfully used for the determination of methionine in serum and feed.Chapter IV: Determination of epinephrine by the Briggs-Rauscher oscillating system using non-equilibrium stationary stateA highly sensitive method for the determination of epinephrine was proposed. The method was based on the perturbation of epinephrine to Briggs-Rauscher oscillating system which was consisted of malonic acid, Mn2+, IO3- and H2O2 in acidic solution at non-equilibrium stationary state. The concentration of KIO3 was chosen as a control parameter to find the bifurcation point. Results showed that a well linear relationship between the changes of potential and the negative logarithm concentrations of epinephrine existed in the range of 1.1×10-75.2×10-9 mol/L with a lower detection limit of 6.8×10-10mol/L. The effects of some foreign species on determination were also investigated. The proposed method has been successfully used to determine the epinephrine both in the serum and adrenaline hydrochloride injection.
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