The Relationship Between Serum Vitamin D Level And Obesity, Metabolic Abnormalities

Objective To investigate the relationship between vitamin D levels and the obsity, metabolic abnormalities. There were 224 subjects with 136 males and 88 females.Methods This study was a cross-sectional study using data on 224 adults who visited Wuhan Union Hospital for a general health checkup from June to September 2009. Vitamin D status was assessed by measuring serum 25-(OH)D.Result The average level of serum 25-(OH)D was 77.05±1.65nmol/l.Men had higher serum 25-(OH)D levels than women (P<0.001),82.92±1.76 nmol/l and 67.98±2.96 nmol/l,respectively.Subjects less than 40 years old was found to have the highest serum 25-(OH)D(P=0.03). The serum 25(-OH)D of overweight or obese and central obese subjects were lower than non-obese subjects.(P<0.001).There was no difference of serum 25(-OH)D between overweight or obese and central obese subjects(P=0.88) as well as metabolic syndrome and non-metabolic syndrome(P=0.22).In a multiple-regression model accounting for age,gender,SBP,DBP,FBG,TC,TG,HDL-C and LDL-C, serum 25-(OH)D was independently associated with BMI (β=-2.30,P=0.04) and WC (β=-0.99,P=0.02).Subjects with normal serum 25-(OH)D had lower age,BMI, TC,TG and LDL-C than subjects with hypovitaminosis D(P<0.05).The prevalence of obesity(P=0.019),central obesity(P=0.015) and hypertension(P=0.016) were higer in subjects with hypovitaminosis D as well.Conclusions The serum vitamin D levels in obesity is lower than in non-obesity. Hypovitaminosis D is associated with obesity and metabolic abnormalities.