Relationship Of Depression To Ventricular Remoding In Patients With Chronic Ischemic Heart Failure

Objective : To compare the magnitude of ventricular remoding between Chronic Ischemic Heart Failure (CIHF)-only group and CIHF puls depression group,and determine the relationship of depression to ventricular remoding in patients with chronic ischemic heart failure .Methods : We screened 117 patients with CIHF , having New York Heart Association ClassⅠ～Ⅲ, admitted between January 2010 and September 2010 , to the vasculocardiology department of Guangdong provincial cardiovascular disease institute .The patients were divided into CIHF-only group (n=80) and depression puls CIHF group (n=37) according to the stanard sore on the Self-Rating Depression Scale , the cut point was≥53 . Transthoracic Echocardiographic assessments of left ventricular end-diastolic dimension index(LVEDDI) , end-systolic dimension index(LVESDI) , relative wall thickness (LVRWT) , mass index(LVMI) , ejection fraction(LVEF) were performed in 117 patients . left ventricular end-diastolic dimension index was the primary end point . Echocardiographic characteritics between two groups were compared to determine the characteritics correlated with depression. Stepwise multiple linear regression analysis was used to confirme whether depression was dependently associated with the echocardiographic characteritics .Results : 1 Patients with CIHF had significantly high prevalence of depress compared with the general population , 31.62%(95%CI23.19%～50.05%)。2 LVEDDI in CIHF and depression group was higher than CIHF-only group, p=0.011.No statistically significant difference of LVESDI,LVRWT,LVMI, LVEF was found between two groups, p=0.075,0.968,0.067,0.209.3 Fasting glucose,total cholesterol,brain natriuretic peptide was statistically significantly independent association with LVEDDI, Beta=-0.2111,0.238,0.232,p=0.046,0025,0.029. No statistically significantly independent association was found between LVEDDI and depression .Conclusions : Patients with CIHF have significantly high prevalence of depression compared with the general population ,depression is common in patients with CIHF. LVEDDI in patients with CIHF and depression are higher than those with CIHF without depression,but no statistically significantly independent association was found between LVEDDI and depression .