The Quality Standards. Stability And Pharmacodynamics Of Sanjie Zhitong Cataplasm

Sanjie ZhiTong Cataplasm mainly by the re-building, diffusa, Prunella, ChuanWu, Araceae, borneol and other traditional Chinese medicine prepared from extracted with Endometriosis, pain swelling effect. For the pathogenesis of breast hyperplasia, prescription weight floor, diffusa Qingrejiedu, swelling pain stasis, liver and stomach and into the second after, the direct breast disease; Prunella can pass the means, the Sanjie pain; ice film Xinsan go channeling, swelling and relieve pain. Combination of various drugs, topical disease location, make the drugs directly to patients, with detoxification Sanjie, active stasis, Tongluozhitong achievements.This article first described cataplasm's traits, and the rebuilding of herbs and medicinal herbs Prunella vulgaris were TLC, borneol were on the identification of gas chromatography. Chinese Pharmacopoeia for the items on the check, mainly done on a limited inspection of aconitine, containing paste volume inspection, excipient and adherence checks. Finally, re-building in polyphyllins I and II were polyphyllins content inspection, borneol borneol content in check as its quality indicators. The results showed that: Sanjie pain Cataplasma heavy floor, Prunella and borneol active ingredients can be extracted; check items which meet the pharmacopoeia requirements; polyphyllins content of each piece not less than 0.070mg, borneol content of each not less than 10mg.On the stability of Cataplasm Sanjie pain pain for Sanjie quality standards Cataplasm project was carried out in the stability test factors (temperature, humidity and light on its effects), accelerated stability test and long-term stability test . The results showed that: Sanjie cataplasm pain response to light and relatively large changes in temperature, the use of aluminum foil packaging can basically stable.Pharmacodynamics for cataplasm was studied, using intramuscular injection of exogenous estradiol benzoate and progesterone way rat model of mammary glands, nipples were observed morphological changes in rats, using RIA Determination of experimental rat model of each group plasma estradiol (E2), progesterone (P) content of the water Ti Babu paste result of low, medium and high treatment group, nipple swelling, breast enlargement and significant small leaves, acinar, ductal hyperplasia and plasma estradiol levels were significantly lower than model group. Compared with alcohol Ti Babu cream, water extraction increased progesterone concentrations in each group and reduce the number and area of acinar more significant, showing a better efficacy of inhibition of mammary gland hyperplasia.