The Association Between Adiposity, Serum Lipid Profile And Mild Cognition Impairment In Middle And Elderly Population

Objective: Obesity is a public health problem of increasing prevalence worldwide. It had been confirmed to cause chronic cordis and cerebral vessels disease. Recent study had also indicated the association between obesity or dyslipidemia and Alzheimer's disease. However, it remains undetermined whether the adiposity and serum lipid profile are also associated with early mild cognition impairment in asymptomatic individuals. We aimed to explore the relations of anthropometric indices of adiposity and serum lipid concentration with middle and elderly population in Guangzhou Biobank Cohort Study and Search for the sensitive biomarker that influence cognitive function. So that to provide the scientific basis for screening mild cognitive impairment(MCI) population and prevention and control dementia.Methods: 19181 subjects aged 50 to 85 years were included in this study from the first and second recruitment phase of the Guangzhou Biobank Cohort Study. The subjects received a face-to-face interviews to collect detailed information on their sociodemographic background, occupational exposures, living environment, lifestyle, family and personal disease histories, and had a physical examination and tests including 12-lead ECG, chest radiograph, and pulmonary function testing. Each subject was tested for a range of fasting biochemical parameters. The cognitive function test was using 10-word delayed recall test. To evaluate the association between adiposity or serum lipid profile and cognition function, we used univariate analyses and multivariate variable analysis. Logistic regression was used to assess the association between anthropometric indices of adiposity or serum lipid profile and mild cognitive impairment.Results: (1) Apart from fasting serum glucose, some lifestyle and physiological and biochemical factors as age, education, smoking status, drinking status, IPAQ, systolic blood pressure(SBP), diastolic blood pressure(DBP), hypertension and diabetes were significant in both gender (P<0.005). (2) With waist to hip ratio(WHR) increasing, 10-word delayed recall test score decreased in both gender. In women, with body mass index(BMI), waist circumference(WC) and waist to height ratio(WHtR) increasing, the score desreased, but the score increase with total cholesterol (TC), high density lipoprotein cholesterol(HDL-c) and low density lipoprotein cholesterol(LDL-c) rising. (3) Multinomial linear regression analyze indicated 10-word delayed recall test score was significantly associated with WHR, TC, HDL-c and LDL-c in both sexs (P<0.01). (4) Logistic regression indicated higher WHR was a risk factor of mild cognitive impairment in women, HDL-c deficit is a risk factor of poorer memory in women; After adjusting age, education, smoking status, drinking status, fasting serum glucose, SBP, DBP, greater WHR and HDL-C deficit was associated with mild cognitive impairment in women (P for trend <0.01).Conclusion: Centripetal obesity was associated with mild cognitive impairment. WHR is a sensitive indicator to influence cognitive function. In women, HDL-C deficit is a risk factor of mild cognitive impairment.