Clinical Significance Of Serum IgG-ACL In Patients With Connective Tissue Disease

Objective Anticardiolipin antibodies(ACL) is a hereogeneous antibody,its target antigen is diphosphoglycetate structure witch is the major membrane lipid composition,is widely distributed in the body of many organizations, was also associated with autoimmune disease closely in recent years . ACL maily IgG,IgM,IgA three types. The total IgG- ACL in the ACL holds a prominent positive rate,and strong clinical relevance. Therefore,this issue was to explore the detection of serum IgG- ACL in the connective tissue disease(CTD)'s clinical significance.Methods Analyzing 213 cases of CTD patient who had tested IgG-ACL ,by non-CTD and normal control groups. CTD group include 64 cases of systemic lupus erythematosus(SLE), 59 cases of rheumatoid arthritis(RA), 32 cases of primary Sjogren's syndrome(pSS), 16 cases of Behcet's disease(BD), 10 cases of systemic sclerosis(SSc), 14 cases of mixed connective tissue disease(MCTD), 10 cases of polymyositis and 8 cases of fibromyalgia syndrome.The non-CTD were a total of 40 case.Including 15 cases of tumor,13 cases of lung infection,7 cases of tuberculosis,5 cases of hyperthyroidism.IgG- ACL were detected by Shenzhen anqiong Group Co,Ltd biological reagents,the use of enzyme-linked immunosorbent assay (ELISA).Analysis the relationship between IgG- ACL and CTD.Results①The three groups had significant differences. The difference significant is between with CTD group and the non-CTD group,also between with CTD group and the normal control group. IgG- ACL positive rate of detection in SLE,RA and pSS is more higher.②In SLE clinical manifestations and laboratory examination, SLEDAI score,complement,ESR,anti-double-stranded DNA antibody binding rate,24h proteinuria and Hypertension,neuropsychiatric symptoms, lupus nephritis ,thrombosis between IgG- ACL -positive and IgG- ACL -negative groups have significant differences.③In RA clinical manifestations and laboratory examination, rheumatoid nodules comparison between IgG- ACL -posistive and IgG- ACL -negative groups was statistically significant.④pSS complicated with autoimmune disease such as thyroid disease,autoimmune liver disease are differences between the IgG- ACL -positive and negative-groups.Conclusions 1.The detection of serum IgG- ACL have an important supporting role to judge connective tissue disease.SLE patients tested positive for IgG- ACL is highest in connective tissue disease.2. Serum IgG-ACL is highly relevant with the SLE disease activity,IgG-type ACL -positive SLE patients easy to occur with lupus nephritis,hypertension,lupus brain disease,complicated by thrombosis. 3. IgG-type ACL–positive adult RA patients easy to occur with vasculitis. 4.IgG- ACL is more common in primary Sjogren's syndrome complicated with autoimmune diseases such as thyroid disease,autoimmune liver disease.