Research Of Blood Pressure Variability's Influence On Arery Stifiness And Left Ventricular Hypertophy In Hypertnesiv Patients

Objective: To explore the blood pressure variability's influence on artery stiffness and leftventricular hypertrophy in patients with essential hypertension.Methods: Blood pressure variability(blood pressure variability,BPV) were monitoredin 120 hypertensive paitents by ambulatory blood pressure monitoring. Brachial-anklewave velocity (brachial-ankle Pulse Wave Velocity,ba-PWV) and Flow-mediated dilation(Flow-Mediated Dilatation,FMD) were examined as artery stiffness (ba-PWV was measuredby VP-1000 automated analyzer, FMD of brachial artery was measured by high resolutionultralsound assessment of the brachial artery diameter). Left ventricular mass index(leftventricular mass index,LVMI) was measured by echocardiography to evaluate the level ofleft ventricular hypertrophy. The data are analyzed by univariate correlation analysis andmultivariate stepwise regression to discuss the factors influencing ba-PWV, FMD and LVMI.Results: On the increase of blood pressure variability, ba-PWV and LVMI became higherand higher (P<0.05), FMD became lower and lower (P<0.05). Univariate correlation analysisdemonstrated that there was a significant relationship between BPV and ba-PWV, BPV and FMD,BPV and LVMI, ba-PWV and FMD, ba-PWV and LVMI, FMD and LVMI. In all recruitedsubjects,multivariate stepwise regression analysis demonstrated that 24hBPVs was significantand independent factors for ba-PWV and FMD and LVMI , also, ba-PWV and FMD wassignificant and independent factors for LVMI.Conclusion: In the hypertensive patients, the increase of BPV can lead to an increase in arterialstiffness and left ventricular hypertrophy. BPV play an important role in hypertensive targetorgan's damage.