The Study On The Relationship Between Folic Acid, Homocysteine And Kazak's Esophageal Cancer

Objective:To understand the nutrition status, folic acid levels and homocysteine levels and research the relationship between folic acid, homocysteine and esophageal cance among Kazak residents in Xinyuan Xinjian, and to provide the basis for correcttion of unhealthy behavior and diet, rational nutrition and balanced diet. Methods:(1)By case-control study, Kazak residents (75 esophageal cancer,150 control group) in Xinyuan Xinjian was interviewed with a uniform questionnaire and did 24-hour dietary review. The content include the basic conditions, smoking, drinking and the intake status of nutrition. (2)Automated chemiluminescence immunoassay determined folic acid levels, high performance liquid chromatography(HPLC) detected plasma homocysteine levels. (3)The intake levels of nutrition were distributed by mean±standard deviationthe data were arranged by multivariate logistic regression analysis to selecct the risk factors of esophageal-cance. Results:(1)The energy, protein, calcium, sodium, iron, vitamin A, thiamine, riboflavin, folic acid intake of esophageal cancer group and control group in the proportion of DRIs were 85.58% and 122.83%,122.65% and 169.82%,75.50% and 95.78%,194.61% and 226.06%,166.43% and 226.47%,64.61% and 91.28%,67.38% and 89.57%,87.13% and 120.44%,7.53% and 32.58% respectively. (2)The levels of folic acid and homocysteine were 6.04±3.89nmol/L and 16.53±5.86μmol/L among the esophageal cancer group. There were statistical significances between the two groups(P<0.05). There were statistical significances between the high levels group and control group (P<0.05). The risk of the high levels group was 0.25 times than the the low levels group. There were statistical significances between the high levels group and control group (P<0.05). The risk of the high levels group was 7.86 times than the low levels group. There were statistical significances between the high levels group and control group (P<0.05). (3)Multivariable logistic analysis showed that the serum folate level is lower than 6.8nmol/L(OR=1.21), the plasma Hcy level is higher than 15μmol/L(OR=2.17), previous esophageal disease(OR=1.08), eating fast(OR=2.06), drinking(OR=2.25), eating smoked meat (OR= 13.05), eating hot food (OR=2.10), related to the occurrence of esophageal cancer(P<0.05). Conclusions:(1)In the esophageal cancer group, the quantity of protein, sodium and iron is higher, the quantity of energy, calcium, vitamin A, thiamine, riboflavin, vitamin C is deficient, the quantity of folic acid is seriously lacking. (2)It suggests that the folic acid level is low, the risk of developing esophageal cancer will increase; the plasma homocysteine level is higher, the risk of esophageal cancer developing esophageal cancer will increase. (3)The risk factors of esophageal cance may be serum folate level is lower than 6.8nmol/L, the plasma Hey level is higher than 15μmol/L, previous esophageal disease, drinking, eating fast, eating smoked meat and eating hot food among Kazak residents.